The α4β7 blockade with vedolizumab is effective in prevention of graft vs. host disease using a xenogeneic mouse model

被引:2
作者
Palaniyandi, Senthilnathan [1 ]
Kumari, Reena [1 ]
Strattan, Ethan [1 ,2 ]
Huang, Timothy [1 ]
Du, Jing [3 ]
Hakim, Natalya [3 ]
Kesler, Melissa V. [3 ]
Hildebrandt, Gerhard C. [1 ,2 ]
机构
[1] Univ Kentucky, Dept Internal Med, Markey Canc Ctr, Div Hematol & Blood & Marrow Transplantat, Lexington, KY 40536 USA
[2] Univ Kentucky, Dept Microbiol Immunol & Mol Genet, Lexington, KY USA
[3] Univ Kentucky, Dept Pathol & Lab Med, Lexington, KY USA
关键词
T-CELLS; INTEGRIN; ANTIBODY;
D O I
10.1002/ajh.25678
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:E39 / E41
页数:3
相关论文
共 10 条
[1]   Expression of α4β7 integrin on memory CD8+ T cells at the presentation of acute intestinal GVHD [J].
Chen, Y-B ;
McDonough, S. ;
Chen, H. ;
Kennedy, J. ;
Illiano, C. ;
Attar, E. C. ;
Ballen, K. K. ;
Dey, B. R. ;
McAfee, S. L. ;
Jagasia, M. ;
Soiffer, R. ;
Spitzer, T. R. ;
Ritz, J. .
BONE MARROW TRANSPLANTATION, 2013, 48 (04) :598-603
[2]   Role of CXCR3-induced donor T-cell migration in acute GVHD [J].
Duffner, U ;
Lu, B ;
Hildebrandt, GC ;
Teshima, T ;
Williams, DL ;
Reddy, P ;
Ordemann, R ;
Clouthier, SG ;
Lowler, K ;
Liu, C ;
Gerard, C ;
Cooke, KR ;
Ferrara, JLM .
EXPERIMENTAL HEMATOLOGY, 2003, 31 (10) :897-902
[3]   Targeting Integrin α4β7 in Steroid-Refractory Intestinal Graft-versus-Host Disease [J].
Floisand, Yngvar ;
Lundin, Knut E. A. ;
Lazarevic, Vladimir ;
Kristiansen, Jorn Dehli ;
Osnes, Liv T. N. ;
Tjonnfjord, Geir E. ;
Reims, Henrik Mikael ;
Gedde-Dahl, Tobias .
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2017, 23 (01) :172-175
[4]   The primacy of the gastrointestinal tract as a target organ of acute graft-versus-host disease: rationale for the use of cytokine shields in allogeneic bone marrow transplantation [J].
Hill, GR ;
Ferrara, JLM .
BLOOD, 2000, 95 (09) :2754-2759
[5]   Target antigens determine graft-versus-host disease phenotype [J].
Kaplan, DH ;
Anderson, BE ;
McNiff, JM ;
Jain, D ;
Shlomchik, MJ ;
Shlomchik, WD .
JOURNAL OF IMMUNOLOGY, 2004, 173 (09) :5467-5475
[6]   LPAM(α4β7 integrin) is an important homing integrin on alloreactive T cells in the development of intestinal graft-versus-host disease [J].
Petrovic, A ;
Alpdogan, O ;
Willis, LM ;
Eng, JM ;
Greenberg, AS ;
Kappel, BJ ;
Liu, C ;
Murphy, GJ ;
Heller, G ;
van den Brink, MRM .
BLOOD, 2004, 103 (04) :1542-1547
[7]  
Picarella D, 1997, J IMMUNOL, V158, P2099
[8]   The Binding Specificity and Selective Antagonism of Vedolizumab, an Anti-α4β7 Integrin Therapeutic Antibody in Development for Inflammatory Bowel Diseases [J].
Soler, Dulce ;
Chapman, Tobias ;
Yang, Li-Li ;
Wyant, Tim ;
Egan, Robert ;
Fedyk, Eric R. .
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2009, 330 (03) :864-875
[9]   A new xenograft model for graft-versus-host disease by intravenous transfer of human peripheral blood mononuclear cells in RAG2-/- γc-/- double-mutant mice [J].
van Rijn, RS ;
Simonetti, ER ;
Hagenbeek, A ;
Hogenes, MCH ;
de Weger, RA ;
Canninga-van Dijk, MR ;
Weijer, K ;
Spits, H ;
Storm, G ;
van Bloois, L ;
Rijkers, G ;
Martens, ACM ;
Ebeling, SB .
BLOOD, 2003, 102 (07) :2522-2531
[10]   An Overview of the Mechanism of Action of the Monoclonal Antibody Vedolizumab [J].
Wyant, Tim ;
Fedyk, Eric ;
Abhyankar, Brihad .
JOURNAL OF CROHNS & COLITIS, 2016, 10 (12) :1437-1444