Treatment of acute deep venous thrombosis and pulmonary embolism: Use of low molecular weight heparin

被引:0
作者
Tapson, VF [1 ]
机构
[1] Duke Univ, Med Ctr, Div Pulm & Crit Care Med, Durham, NC 27710 USA
关键词
deep venous thrombosis; pulmonary embolism; anticoagulation; low molecular weight heparin; heparin;
D O I
暂无
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Over the past decade, the use of low molecular weight heparin (LMWH) preparations has revolutionized the approach to preventing and treating venous thromboembolism. For established deep venous thrombosis, numerous prospective clinical trials have indicated that these drugs are at least as safe and as effective as standard, unfractionated heparin (UFH) and perhaps even more effective at preventing recurrences. Advantages of low molecular weight heparin include superior bioavailability compared with standard heparin, once- or twice-daily subcutaneous delivery, and the lack of need to monitor in most clinical circumstances, Because of these advantages, increasing numbers of stable, compliant patients with deep venous thrombosis are being treated as outpatients. This approach requires an organized team effort with comprehensive patient education and carefully planned follow-up. Cost-benefit analyses have unequivocally proved that when treatment with low molecular weight heparin is utilized in the outpatient setting, there are substantial cost savings.
引用
收藏
页码:547 / 553
页数:7
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