Evidence for Functional Networks within the Human Brain's White Matter

被引:169
作者
Peer, Michael [1 ,2 ]
Nitzan, Mor [3 ,4 ,5 ]
Bick, Atira S. [2 ]
Levin, Netta [2 ]
Arzyt, Shahar [1 ,2 ]
机构
[1] Hadassah Hebrew Univ, Med Sch, Computat Neuropsychiat Lab, Dept Med Neurosci, IL-91120 Jerusalem, Israel
[2] Hadassah Hebrew Univ, Med Ctr, Dept Neurol, IL-91120 Jerusalem, Israel
[3] Hebrew Univ Jerusalem, Racah Inst Phys, IL-90401 Jerusalem, Israel
[4] Hebrew Univ Jerusalem, Dept Microbiol & Mol Genet, Inst Med Res Israel Canada, Fac Med, IL-91120 Jerusalem, Israel
[5] Hebrew Univ Jerusalem, Sch Comp Sci, IL-90401 Jerusalem, Israel
基金
以色列科学基金会;
关键词
BOLD; clustering; fMRI; functional connectivity; resting state; tract; HUMAN CEREBRAL-CORTEX; STRUCTURAL CONNECTIVITY; ANATOMICAL STRUCTURES; HEAD MOTION; ORGANIZATION; ACTIVATION; BOLD; ARCHITECTURE; GRAY;
D O I
10.1523/JNEUROSCI.3872-16.2017
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Investigation of the functional macro-scale organization of the human cortex is fundamental in modern neuroscience. Although numerous studies have identified networks of interacting functional modules in the gray-matter, limited research was directed to the functional organization of the white-matter. Recent studies have demonstrated that the white-matter exhibits blood oxygen level-dependent signal fluctuations similar to those of the gray-matter. Here we used these signal fluctuations to investigate whether the white-matter is organized as functional networks by applying a clustering analysis on resting-state functional MRI (RSfMRI) data from white-matter voxels, in 176 subjects (of both sexes). This analysis indicated the existence of 12 symmetrical white-matter functional networks, corresponding to combinations of white-matter tracts identified by diffusion tensor imaging. Six of the networks included interhemispheric commissural bridges traversing the corpus callosum. Signals in white-matter networks correlated with signals from functional gray-matter networks, providing missing knowledge on how these distributed networks communicate across large distances. These findings were replicated in an independent subject group and were corroborated by seed-based analysis in small groups and individual subjects. The identified white-matter functional atlases and analysis codes are available at http://mind.huji.ac.il/white-matter.aspx. Our results demonstrate that the white-matter manifests an intrinsic functional organization as interacting networks of functional modules, similarly to the gray-matter, which can be investigated using RSfMRI. The discovery of functional networks within the white-mattermayopen new avenues of research in cognitive neuroscience and clinical neuropsychiatry.
引用
收藏
页码:6394 / 6407
页数:14
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