Design and development of polysaccharide hemostatic materials and their hemostatic mechanism

被引：242

作者：

Yang, Xiao ^{[1
]}

Liu, Wen ^{[2
,3
]}

Li, Na ^{[2
,3
]}

Wang, Mingshan ^{[4
]}

Liang, Bin ^{[4
]}

Ullah, Ihsan ^{[1
]}

Neve, Agnaldo Luis ^{[1
]}

Feng, Yakai ^{[1
,2
,3
,5
,6
]}

Chen, Hao ^{[2
,3
]}

Shi, Changcan ^{[2
,3
]}

机构：

[1] Tianjin Univ, Sch Chem Engn & Technol, Collaborat Innovat Ctr Chem Sci & Chem Engn Tianj, Tianjin 300072, Peoples R China

[2] Chinese Acad Sci, Wenzhou Inst Biomat & Engn, CNITECH, Wenzhou 325011, Zhejiang, Peoples R China

[3] Wenzhou Med Univ, Sch Biomed Engn, Eye Hosp, Sch Ophthalmol Optometry, Wenzhou 325000, Zhejiang, Peoples R China

[4] Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou 325000, Zhejiang, Peoples R China

[5] Tianjin Univ Helmholtz Zentrum Geesthacht, Joint Lab Biomat & Regenerat Med, Tianjin 300350, Peoples R China

[6] Tianjin Univ, Key Lab Syst Bioengn, Minist Educ, Tianjin 300072, Peoples R China

来源：

BIOMATERIALS SCIENCE | 2017年 / 5卷 / 12期

基金：

中国博士后科学基金; 中国国家自然科学基金; 对外科技合作项目（国际科技项目）; 国家重点研发计划;

关键词：

TISSUE ADHESIVE; CHONDROITIN SULFATE; BLOOD-COAGULATION; HYALURONIC-ACID; COMBAT GAUZE; IN-VITRO; CHITOSAN; CELLULOSE; ALGINATE; HYDROGEL;

D O I：

10.1039/c7bm00554g

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

The formation of stable blood clots or hemostasis is essential to prevent major blood loss and death from excessive bleeding. However, the body's own coagulation process is not able to accomplish timely hemostasis without the assistance of hemostatic agents. For developing novel topical hemostatic agents, tissue adhesives and sealants, it is necessary to understand the coagulation process and the hemostasis mechanism of different materials. Among hemostatic materials, polysaccharides are naturally derived polymers having excellent biodegradable and biocompatible properties. This review provides an overview of polysaccharide-based hemostatic materials and agents, including their advantages and drawbacks in hemostatic applications. Furthermore, polysaccharide-based hemostatic materials with anti-microbial and healing functions are also introduced.

引用

页码：2357 / 2368

页数：12

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