Persistent T-Cell Reactivity in a Seronegative Patient after SARS-CoV-2 Infection and One Vaccination

被引:3
作者
Andreas, Nico [1 ]
Weis, Sebastian [2 ,3 ]
Kolanos, Steffi [2 ]
Baumgart, Sabine [4 ]
Kamradt, Thomas [1 ]
Pletz, Mathias W. [1 ,2 ,4 ]
机构
[1] Friedrich Schiller Univ, Jena Univ Hosp, Inst Immunol, D-07743 Jena, Germany
[2] Friedrich Schiller Univ, Jena Univ Hosp, Inst Infect Dis & Infect Control, D-07747 Jena, Germany
[3] Hans Knoell Inst, Leibniz Inst Nat Prod Res & Infect Biol, D-07745 Jena, Germany
[4] Friedrich Schiller Univ, Jena Univ Hosp, Inst Immunol, Core Facil Cytometry, D-07743 Jena, Germany
关键词
CoNAN; Neustadt am Rennsteig; COVID-19; SARS-CoV-2; T cell responses; T immunity; antibodies;
D O I
10.3390/vaccines10010114
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
We present here a 64-year-old male participant of the CoNAN study who experienced a PCR-confirmed mild SARS-CoV-2 infection but did not develop any measurable antibody response. Additionally, after vaccination with ChAdOx1 (AstraZeneca, Cambridge, UK) 11 months later, no antibodies were detected in six serological tests three weeks after the vaccination. When we assessed T-helper (Th) cell immunity, SARS-CoV-2-specific Th cells produced detectable amounts of IFN gamma and TNF six weeks after the infection. A robust T-cell immunity remained detectable at least until six months after the infection and was boosted by the vaccination thereafter. This case report points out that an assessment of a prior infection or a vaccine response based solely on antibody detection might have limitations in individual patients.
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