Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia

被引：38

作者：

Corces, M. Ryan ^{[1
,2
]}

Chang, Howard Y. ^{[1
,2
]}

Majeti, Ravindra ^{[3
]}

机构：

[1] Stanford Univ, Sch Med, Ctr Personal Dynam Regulomes, Stanford, CA USA

[2] Stanford Univ, Sch Med, Program Epithelial Biol, Stanford, CA USA

[3] Stanford Univ, Sch Med, Ludwig Ctr,Canc Inst, Inst Stem Cell Biol & Regenerat Med,Program Canc, Stanford, CA 94305 USA

来源：

FRONTIERS IN ONCOLOGY | 2017年 / 7卷

关键词：

leukemia; myeloid; acute; preleukemic hematopoietic stem cell; clonal hematopoiesis; clonal evolution; premalignant lesions; ACUTE LYMPHOBLASTIC-LEUKEMIA; LONG-TERM REMISSION; CLONAL HEMATOPOIESIS; MYELOGENOUS LEUKEMIA; SOMATIC MUTATIONS; TET2; EVOLUTION; IMATINIB; DNMT3A; ORIGINS;

D O I：

10.3389/fonc.2017.00263

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Acute myeloid leukemia (AML) is an aggressive malignancy of the bone marrow characterized by an uncontrolled proliferation of undifferentiated myeloid lineage cells. Decades of research have demonstrated that AML evolves from the sequential acquisition of genetic alterations within a single lineage of hematopoietic cells. More recently, the advent of high-throughput sequencing has enabled the identification of a premalignant phase of AML termed preleukemia. Multiple studies have demonstrated that AML can arise from the accumulation of mutations within hematopoietic stem cells (HSCs). These HSCs have been termed "preleukemic HSCs" as they represent the evolutionary ancestors of the leukemia. Through examination of the biological and clinical characteristics of these preleukemic HSCs, this review aims to shed light on some of the unexplored questions in the field. We note that some of the material discussed is speculative in nature and is presented in order to motivate future work.

引用

页数：8

共 75 条

[1] DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions [J].

Buscarlet, Manuel ;

Provost, Sylvie ;

Zada, Yassamin Feroz ;

Barhdadi, Amina ;

Bourgoin, Vincent ;

Lepine, Guylaine ;

Mollica, Luigina ;

Szuber, Natasha ;

Dube, Marie-Pierre ;

Busque, Lambert .

BLOOD, 2017, 130 (06) :753-762

[2] Recurrent somatic TET2 mutations in normal elderly individuals with clonal hematopoiesis [J].

Busque, Lambert ;

Patel, Jay P. ;

Figueroa, Maria E. ;

Vasanthakumar, Aparna ;

Provost, Sylvie ;

Hamilou, Zineb ;

Mollica, Luigina ;

Li, Juan ;

Viale, Agnes ;

Heguy, Adriana ;

Hassimi, Maryam ;

Socci, Nicholas ;

Bhatt, Parva K. ;

Gonen, Mithat ;

Mason, Christopher E. ;

Melnick, Ari ;

Godley, Lucy A. ;

Brennan, Cameron W. ;

Abdel-Wahab, Omar ;

Levine, Ross L. .

NATURE GENETICS, 2012, 44 (11) :1179-1181

[3] Dnmt3a is essential for hematopoietic stem cell differentiation [J].

Challen, Grant A. ;

Sun, Deqiang ;

Jeong, Mira ;

Luo, Min ;

Jelinek, Jaroslav ;

Berg, Jonathan S. ;

Bock, Christoph ;

Vasanthakumar, Aparna ;

Gu, Hongcang ;

Xi, Yuanxin ;

Liang, Shoudan ;

Lu, Yue ;

Darlington, Gretchen J. ;

Meissner, Alexander ;

Issa, Jean-Pierre J. ;

Godley, Lucy A. ;

Li, Wei ;

Goodell, Margaret A. .

NATURE GENETICS, 2012, 44 (01) :23-U43

[4] Acquired somatic mutations of isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) in preleukemic disorders [J].

Chotirat, Sadudee ;

Thongnoppakhun, Wanna ;

Wanachiwanawin, Wanchai ;

Auewarakul, Chirayu U. .

BLOOD CELLS MOLECULES AND DISEASES, 2015, 54 (03) :286-291

[5] Therapy-Related Clonal Hematopoiesis in Patients with Non-hematologic Cancers Is Common and Associated with Adverse Clinical Outcomes [J].

Coombs, Catherine C. ;

Zehir, Ahmet ;

Devlin, Sean M. ;

Kishtagari, Ashwin ;

Syed, Aijazuddin ;

Jonsson, Philip ;

Hyman, David M. ;

Solit, David B. ;

Robson, Mark E. ;

Baselga, Jose ;

Arcila, Maria E. ;

Ladanyi, Marc ;

Tallman, Martin S. ;

Levine, Ross L. ;

Berger, Michael F. .

CELL STEM CELL, 2017, 21 (03) :374-+

[6] Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity [J].

Corbin, Amie S. ;

Agarwal, Anupriya ;

Loriaux, Marc ;

Cortes, Jorge ;

Deininger, Michael W. ;

Druker, Brian J. .

JOURNAL OF CLINICAL INVESTIGATION, 2011, 121 (01) :396-409

[7] Lineage-specific and single-cell chromatin accessibility charts human hematopoiesis and leukemia evolution [J].

Corces, M. Ryan ;

Buenrostro, Jason D. ;

Wu, Beijing ;

Greenside, Peyton G. ;

Chan, Steven M. ;

Koenig, Julie L. ;

Snyder, Michael P. ;

Pritchard, Jonathan K. ;

Kundaje, Anshul ;

Gkeenleaf, William J. ;

Majeti, Ravindra ;

Chang, Howard Y. .

NATURE GENETICS, 2016, 48 (10) :1193-1203

[8] Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis [J].

Corces-Zimmerman, M. R. ;

Majeti, R. .

LEUKEMIA, 2014, 28 (12) :2276-2282

[9] Preleukemic mutations in human acute myeloid leukemia affect epigenetic regulators and persist in remission [J].

Corces-Zimmerman, M. Ryan ;

Hong, Wan-Jen ;

Weissman, Irving L. ;

Medeiros, Bruno C. ;

Majeti, Ravindra .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2014, 111 (07) :2548-2553

[10] Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing [J].

Ding, Li ;

Ley, Timothy J. ;

Larson, David E. ;

Miller, Christopher A. ;

Koboldt, Daniel C. ;

Welch, John S. ;

Ritchey, Julie K. ;

Young, Margaret A. ;

Lamprecht, Tamara ;

McLellan, Michael D. ;

McMichael, Joshua F. ;

Wallis, John W. ;

Lu, Charles ;

Shen, Dong ;

Harris, Christopher C. ;

Dooling, David J. ;

Fulton, Robert S. ;

Fulton, Lucinda L. ;

Chen, Ken ;

Schmidt, Heather ;

Kalicki-Veizer, Joelle ;

Magrini, Vincent J. ;

Cook, Lisa ;

McGrath, Sean D. ;

Vickery, Tammi L. ;

Wendl, Michael C. ;

Heath, Sharon ;

Watson, Mark A. ;

Link, Daniel C. ;

Tomasson, Michael H. ;

Shannon, William D. ;

Payton, Jacqueline E. ;

Kulkarni, Shashikant ;

Westervelt, Peter ;

Walter, Matthew J. ;

Graubert, Timothy A. ;

Mardis, Elaine R. ;

Wilson, Richard K. ;

DiPersio, John F. .

NATURE, 2012, 481 (7382) :506-510

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