A Conserved Archaeal Pathway for Tail-Anchored Membrane Protein Insertion

被引：12

作者：

Sherrill, John ^{[1
]}

Mariappan, Malaiyalam ^{[2
]}

Dominik, Pawel ^{[1
]}

Hegde, Ramanujan S. ^{[2
]}

Keenan, Robert J. ^{[1
]}

机构：

[1] Univ Chicago, Dept Biochem & Mol Biol, Gordon Ctr Integrat Sci, Chicago, IL 60637 USA

[2] NICHHD, Cell Biol & Metab Program, NIH, Bethesda, MD 20892 USA

来源：

TRAFFIC | 2011年 / 12卷 / 09期

关键词：

archaea; ArsA; Get3; insertion; posttranslational; targeting; tail-anchored membrane proteins; TRC40; BINDING; COMPLEX; GET3;

D O I：

10.1111/j.1600-0854.2011.01229.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Eukaryotic tail-anchored ( TA) membrane proteins are inserted into the endoplasmic reticulum by a posttranslational TRC40 pathway, but no comparable pathway is known in other domains of life. The crystal structure of an archaebacterial TRC40 sequence homolog bound to ADP.AlF4- reveals characteristic features of eukaryotic TRC40, including a zinc-mediated dimer and a large hydrophobic groove. Moreover, archaeal TRC40 interacts with the transmembrane domain of TA substrates and directs their membrane insertion. Thus, the TRC40 pathway is more broadly conserved than previously recognized.

引用

页码：1119 / 1123

页数：5

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