New Delhi metallo-β-lactamase-1: local acquisition in Ontario, Canada, and challenges in detection

被引：32

作者：

Kus, Julianne V. ^{[1
,2
]}

Tadros, Manal ^{[2
,3
]}

Simor, Andrew ^{[2
,3
]}

Low, Donald E. ^{[1
,4
]}

McGeer, Allison J. ^{[1
,2
]}

Willey, Barbara M. ^{[1
]}

Larocque, Cindy ^{[1
]}

Pike, Karen ^{[1
]}

Edwards, Iris-Ann ^{[1
]}

Dedier, Helen ^{[1
]}

Melano, Roberto ^{[2
,4
]}

Boyd, David A. ^{[5
]}

Mulvey, Michael R. ^{[5
]}

Louie, Lisa ^{[3
]}

Okeahialam, Christopher ^{[6
]}

Bayley, Mark ^{[2
,6
]}

Whitehead, Cynthia ^{[2
,6
]}

Richardson, Denyse ^{[2
,6
]}

Carr, Lesley ^{[2
,3
]}

Jinnah, Fatema ^{[3
]}

Poutanen, Susan M. ^{[1
,2
]}

机构：

[1] Mt Sinai Hosp, Joseph & Wolf Lebovic Hlth Complex Dept Microbiol, Toronto, ON M5G 1X5, Canada

[2] Univ Toronto, Toronto, ON, Canada

[3] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

[4] Ontario Agcy Hlth Protect & Promot, Toronto, ON, Canada

[5] Publ Hlth Agcy Canada, Winnipeg, MB, Canada

[6] Toronto Rehabil Inst, Toronto, ON, Canada

来源：

CANADIAN MEDICAL ASSOCIATION JOURNAL | 2011年 / 183卷 / 11期

关键词：

METALLO-BETA-LACTAMASE;

D O I：

10.1503/cmaj.110477

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

New Delhi metallo-beta-lactamase-1 (NDM-1) is a recently identified metallo-beta-lactamase that confers resistance to carbapenems and all other beta-lactam antibiotics, with the exception of aztreonam. NDM-1 is also associated with resistance to many other classes of antibiotics. The enzyme was first identified in organisms isolated from a patient in Sweden who had previously received medical treatment in India, but it is now recognized as endemic throughout India and Pakistan and has spread worldwide. The gene encoding NDM-1 has been found predominantly in Escherichia coli and Klebsiella pneumoniae. We describe the isolation NDM-1-producing organisms from two patients in Toronto, Ontario. To the best of our knowledge, this is the first report of an organism producing NDM-1 that was locally acquired in Canada. We also discuss the evidence that NDM-1 can affect bacterial species other than E. coli and K. pneumoniae, the limited options for treatment and the difficulty laboratories face in detecting organisms that produce NDM-1.

引用

页码：1257 / 1261

页数：5

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