Pretargeted PET Imaging Using a Bioorthogonal 18F-Labeled trans-Cyclooctene in an Ovarian Carcinoma Model

被引：43

作者：

Billaud, Emilie M. F. ^{[1
]}

Belderbos, Sarah ^{[2
]}

Cleeren, Frederik ^{[1
]}

Maest, Wim ^{[3
]}

Van de Wouwer, Marlies ^{[3
]}

Koole, Michel ^{[4
,5
]}

Verbruggen, Alfons ^{[1
]}

Hirnmelreich, Uwe ^{[2
]}

Geukens, Nick ^{[3
]}

Bormans, Guy ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Dept Pharmaceut & Pharmacol Sci, Lab Radiopharmaceut Res, Campus Gasthuisberg,O&N2,Herestr 49,Box 821, B-3000 Leuven, Belgium

[2] Katholieke Univ Leuven, Dept Imaging & Pathol, Biomed MRI MoSAIC, Campus Gasthuisberg,O&N1,Herestr 49,Box 505, B-3000 Leuven, Belgium

[3] Katholieke Univ Leuven, KU Leuven Antibody Ctr, PharmAbs, Campus Gasthuisberg,O&N2,Herestr 49,Box 820, B-3000 Leuven, Belgium

[4] Univ Hosp, Dept Imaging & Pathol, Nucl Med & Mol Imaging, Herestr 49,Box 7003, B-3000 Leuven, Belgium

[5] Katholieke Univ Leuven, Herestr 49,Box 7003, B-3000 Leuven, Belgium

来源：

BIOCONJUGATE CHEMISTRY | 2017年 / 28卷 / 12期

关键词：

POSITRON-EMISSION-TOMOGRAPHY; ALDER CLICK CHEMISTRY; IN-VIVO CHEMISTRY; TETRAZINE LIGATION; IMPROVED STABILITY; BREAST-CANCER; ANTIBODY; PROBES; ZR-89-TRASTUZUMAB; REACTIVITY;

D O I：

10.1021/acs.bioconjchem.7b00635

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

In cancer research, pretargeted positron emission tomography (PET) imaging has emerged as an effective two-step approach that combines the excellent target affinity and selectivity of antibodies with the advantages of using short-lived radionuclides such as fluorine-18. One possible approach is based on the bioorthogonal inverse-electron-demand Diels-Alder (IEDDA) reaction between tetrazines and trans-cyclo-octene (TCO) derivatives. Here, we report the first successful use of an F-18-labeled small TCO compound, [F-18] 1 recently developed in our laboratory, to perform pretargeted immuno-PET imaging. The study was performed in an ovarian carcinoma mouse model, using a trastuzumab-tetrazine conjugate.

引用

页码：2915 / 2920

页数：6

共 44 条

[1] A Pretargeted Approach for the Multimodal PET/NIRF Imaging of Colorectal Cancer [J].

Adumeau, Pierre ;

Carnazza, Kathryn E. ;

Brand, Christian ;

Carlin, Sean D. ;

Reiner, Thomas ;

Agnew, Brian J. ;

Lewis, Jason S. ;

Zeglis, Brian M. .

THERANOSTICS, 2016, 6 (12) :2267-2277

[2] Feasibility of Affibody-Based Bioorthogonal Chemistry Mediated Radionuclide Pretargeting [J].

Altai, Mohamed ;

Perols, Anna ;

Tsourma, Maria ;

Mitran, Bogdan ;

Honarvar, Hadis ;

Robillard, Marc ;

Rossin, Raffaella ;

ten Hoeve, Wolter ;

Lubberink, Mark ;

Orlova, Anna ;

Karlstrom, Amelie Eriksson ;

Tolmachev, Vladimir .

JOURNAL OF NUCLEAR MEDICINE, 2016, 57 (03) :431-436

[3] Micro-flow photosynthesis of new dienophiles for inverse-electron-demand Diels-Alder reactions. Potential applications for pretargeted in vivo PET imaging [J].

Billaud, Emilie M. F. ;

Shahbazali, Elnaz ;

Ahamed, Muneer ;

Cleeren, Frederik ;

Noel, Timothy ;

Koole, Michel ;

Verbruggen, Alfons ;

Hessel, Volker ;

Bormans, Guy .

CHEMICAL SCIENCE, 2017, 8 (02) :1251-1258

[4] Tetrazine ligation: Fast bioconjugation based on inverse-electron-demand Diels-Alder reactivity [J].

Blackman, Melissa L. ;

Royzen, Maksim ;

Fox, Joseph M. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (41) :13518-+

[5] Vedolizumab: an α4β7 integrin antagonist for ulcerative colitis and Crohn's disease [J].

Cherry, Lauren N. ;

Yunker, Nancy S. ;

Lambert, Erika R. ;

Vaughan, DaleMarie ;

Lowe, Denise K. .

THERAPEUTIC ADVANCES IN CHRONIC DISEASE, 2015, 6 (05) :224-233

[6] Pretargeted PET Imaging Using a Site-Specifically Labeled Immunoconjugate [J].

Cook, Brendon E. ;

Adumeau, Pierre ;

Membreno, Rosemery ;

Carnazza, Kathryn E. ;

Brand, Christian ;

Reiner, Thomas ;

Agnew, Brian J. ;

Lewis, Jason S. ;

Zeglis, Brian M. .

BIOCONJUGATE CHEMISTRY, 2016, 27 (08) :1789-1795

[7] Conformationally strained trans-cyclooctene with improved stability and excellent reactivity in tetrazine ligation [J].

Darko, Ampofo ;

Wallace, Stephen ;

Dmitrenko, Olga ;

Machovina, Melodie M. ;

Mehl, Ryan A. ;

Chin, Jason W. ;

Fox, Joseph M. .

CHEMICAL SCIENCE, 2014, 5 (10) :3770-3776

[8] Reactive polymer enables efficient in vivo bioorthogonal chemistry [J].

Devaraj, Neal K. ;

Thurber, Greg M. ;

Keliher, Edmund J. ;

Marinelli, Brett ;

Weissleder, Ralph .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (13) :4762-4767

[9] Fast and Sensitive Pretargeted Labeling of Cancer Cells through a Tetrazine/trans-Cyclooctene Cycloaddition [J].

Devaraj, Neal K. ;

Upadhyay, Rabi ;

Hatin, Jered B. ;

Hilderbrand, Scott A. ;

Weissleder, Ralph .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (38) :7013-7016

[10] Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging [J].

Devaraj, Neal K. ;

Weissleder, Ralph ;

Hilderbrand, Scott A. .

BIOCONJUGATE CHEMISTRY, 2008, 19 (12) :2297-2299

← 1 2 3 4 5 →