Spectrum of changes in placenta in toxemia of pregnancy

被引:19
作者
Narasimha, Aparna [1 ]
Vasudeva, D. S. [2 ]
机构
[1] Sri Devraj Urs Acad Higher Educ & Res, Dept Pathol, Tamaka, Kolar, India
[2] Dr BR Ambedkar Med Coll, Bangalore, Karnataka, India
关键词
Calcification; eclampsia; infarction; preeclampsia; villous abnormalities;
D O I
10.4103/0377-4929.77317
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Background: Toxemia of pregnancy is the leading cause of maternal mortality and is an important factor in fetal wastage. The incidence is high in developing countries with malnutrition, hypoproteinemia, and poor obstetric facilities. Objectives: The present study was undertaken to analyze placental changes in the preeclampsia-eclampsia syndrome with a view to assess the significance of villous abnormalities by histopathological methods because these changes serve as a guide to the duration and severity of disease. Gross abnormalities noted were the placental infarcts, retroplacental hematoma, and calcification. Results: The striking villous abnormalities observed in the study group were cytotrophoblastic proliferation (86%), thickening of the villous basement membranes (95.23%), increase in syncytial knots (90.4%), villous stromal fibrosis (92%), fibrinoid necrosis (97.82%), endarteritis obliterans (53.96%), decreased villous vascularity, and paucity of vasculosyncytial membranes (93.65%). Conclusions: The gross abnormalities and villous lesions in the preeclampsia (P < 0.001) and eclampsia syndrome (P < 0.05) were significant.
引用
收藏
页码:15 / 20
页数:6
相关论文
共 18 条
[1]  
BHATIA A, 1981, Indian Journal of Pathology and Microbiology, V24, P277
[2]  
BROWNE JCM, 1953, J OBSTET GYN BRIT EM, V60, P141
[3]   THE CLASSIFICATION AND DEFINITION OF THE HYPERTENSIVE DISORDERS OF PREGNANCY [J].
DAVEY, DA ;
MACGILLIVRAY, I .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1988, 158 (04) :892-898
[4]  
FOX H, 1964, J OBSTET GYN BR COMM, V71, P885
[5]  
Fox H, 1968, J Obstet Gynaecol Br Commonw, V75, P302
[6]  
Fox H, 1995, HAINES TAYLOR OBSTET, P1480
[7]  
Fox H, 2007, PATHOLOGY PLACENTA, P100
[8]  
Kalra VB., 1985, J OBSTET GYNAECOL IN, V35, P86
[9]  
KHER A V, 1981, Indian Journal of Pathology and Microbiology, V24, P245
[10]  
MALLIK G B, 1979, Journal of Obstetrics and Gynaecology of India, V29, P805