Ultrastructural changes in cardiomyocyte mitochondria during regenerative and plastic insufficiency of the myocardium

被引：1

作者：

Nepomnyashchikh, LM ^{[1
]}

Lushnikova, EL ^{[1
]}

Semenov, DE ^{[1
]}

机构：

[1] Russian Acad Med Sci, Siberian Div, Inst Reg Pathol & Pathomorphol, Lab Gen Pathol Anat, Novosibirsk, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2001年 / 131卷 / 02期

关键词：

anthracycline-induced cardiomyopathy; regenerative and plastic insufficiency; cardiomyocytes; mitochondria; ultrastructure;

D O I：

10.1023/A:1017560416147

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Daunomycin-induced regenerative and plastic insufficiency of the myocardium was accompanied by accumulation of cardiomyocytes with unstable mitochondrial membranes containing enlarged mitochondria with lightened matrix and fragmented cristae. Total destabilization of mitochondrial membranes was found in cardiomyocytes with most pronounced ultrastructural signs of impaired protein synthesis. These changes in mitochondria were permanent, which suggested that swelling and destruction of cristae were related to intravital decrease in mitochondrial membrane stability.

引用

页码：181 / 185

页数：5

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