Oral administration of Bifidobacterium bifidum G9-1 suppresses total and antigen specific immunoglobulin E production in mice

被引:47
作者
Ohno, H [1 ]
Tsunemine, S [1 ]
Isa, Y [1 ]
Shimakawa, M [1 ]
Yamamura, H [1 ]
机构
[1] Biofermin Pharmaceut Co Ltd, Dept Res & Dev, Nishi Ku, Kobe, Hyogo 6512242, Japan
关键词
Bifidobacterium bifidum; immunoglobulin E; ovalbumin (OVA); oral administration; allergic disease;
D O I
10.1248/bpb.28.1462
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Recent studies have suggested that oral bacteriotherapy with probiotics might be useful in the management of allergic diseases. We investigated the effect of oral administration of Bifidobacterium bifidum G9-1 (BBG9-1) on immunoglobulin (Ig) E production in BALB/c mice. Live BBG9-1 was orally administered to mice for 2 weeks from I week before ovalbumin (OVA)-immunization. The treatment of BBG9-1 significantly reduced serum total IgE level. In addition, BBG9-1 significantly and largely reduced the serum level of OVA-specific IgE without lowering of the specific IgG1 and increasing of the specific IgG2a. We also examined T helper type (Th)1 and Th2 cytokine production from OVA-immunized splenocytes by restimulation with OVA in vitro. Productions of interferon (IFN)-gamma, interleukin (IL)-4 and IL-5 from the splenocytes of mice given BBG9-1 were weaker than those of control mice. We conclude that oral administration of BBG9-1 selectively and powerfully suppresses total and antigen specific IgE production in mice. It is suggested that BBG9-1 is useful for the prophylactic treatment in IgE-dependent allergic diseases.
引用
收藏
页码:1462 / 1466
页数:5
相关论文
共 37 条
[1]   Allergy development and the intestinal microflora during the first year of life [J].
Björkstén, B ;
Sepp, E ;
Julge, K ;
Voor, T ;
Mikelsaar, M .
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (04) :516-520
[2]  
Björkstén B, 1999, CLIN EXP ALLERGY, V29, P342, DOI 10.1046/j.1365-2222.1999.00560.x
[3]   REGULATORY T-CELL CLONES INDUCED BY ORAL TOLERANCE - SUPPRESSION OF AUTOIMMUNE ENCEPHALOMYELITIS [J].
CHEN, YH ;
KUCHROO, VK ;
INOBE, J ;
HAFLER, DA ;
WEINER, HL .
SCIENCE, 1994, 265 (5176) :1237-1240
[4]   Oral tolerance in myelin basic protein T-cell receptor transgenic mice: Suppression of autoimmune encephalomyelitis and dose-dependent induction of regulatory cells [J].
Chen, YH ;
Inobe, J ;
Kuchroo, VK ;
Baron, JL ;
Janeway, CA ;
Weiner, HL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (01) :388-391
[5]   PERIPHERAL DELETION OF ANTIGEN-REACTIVE T-CELLS IN ORAL TOLERANCE [J].
CHEN, YH ;
INOBE, J ;
MARKS, R ;
GONNELLA, P ;
KUCHROO, VK ;
WEINER, HL .
NATURE, 1995, 376 (6536) :177-180
[6]  
FINKELMAN FD, 1988, J IMMUNOL, V140, P1022
[7]  
Fooks LJ, 2002, BRIT J NUTR, V88, pS39, DOI [10.1079/BJNBJN2002591, 10.1079/BJN2002628]
[8]   INDUCTION OF ANERGY OR ACTIVE SUPPRESSION FOLLOWING ORAL TOLERANCE IS DETERMINED BY ANTIGEN DOSAGE [J].
FRIEDMAN, A ;
WEINER, HL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) :6688-6692
[9]   The anti-allergic effects of lactic acid bacteria are strain dependent and mediated by effects on both Th1/Th2 cytokine expression and balance [J].
Fujiwara, D ;
Inoue, S ;
Wakabayashi, H ;
Fujii, T .
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, 2004, 135 (03) :205-215
[10]  
He F, 2001, FEMS IMMUNOL MED MIC, V30, P43, DOI 10.1016/S0928-8244(00)00232-7