A study of Parkinson's disease patients' serum using FTIR spectroscopy

被引：10

作者：

Wang, Xin ^{[1
]}

Wu, Qipeng ^{[1
]}

Li, Chao ^{[2
]}

Zhou, Yuan ^{[1
]}

Xu, Fangcheng ^{[3
]}

Zong, Ling ^{[1
]}

Ge, Shaolin ^{[4
]}

机构：

[1] Anhui Med Univ, Sch Basic Med Sci, Hefei 230032, Anhui, Peoples R China

[2] Anhui Med Univ, Affiliated Hosp 2, Hefei 230601, Anhui, Peoples R China

[3] Anhui Med Univ, Affiliated Hosp 1, Hefei 230032, Anhui, Peoples R China

[4] China Tobacco Anhui Ind Co Ltd, Key Lab Tobacco Chem Anhui Prov, Hefei 230088, Anhui, Peoples R China

来源：

INFRARED PHYSICS & TECHNOLOGY | 2020年 / 106卷

基金：

中国国家自然科学基金;

关键词：

PD; FTIR spectroscopy; Serum; Early diagnosis; QUANTITATIVE CHANGES; MICROSPECTROSCOPY; PHOSPHOLIPIDS; DIFFERENTIATION; HIPPOCAMPUS; APOPTOSIS; TISSUES; PEOPLE; CELLS;

D O I：

10.1016/j.infrared.2020.103279

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Parkinson's disease (PD) threatens human beings' life and health largely, and early diagnosis of PD is important for its treatment. Fourier transform infrared (FTIR) spectroscopy can detect biomacromolecular changes in cells/tissues sensitively. In this study, we compared PD patients' and healthy persons' serum using FTIR spectroscopy and obtained the following results: 1. Significant differences were existed between peak-area ratios such as A3294/A3067, A1399/A1451 and A1243/A1313. 2. The protein secondary structure changed after PD occurred. 3. The combination of IR spectra and discriminant analysis could distinguish PD patients from healthy persons with 93.44% the sensitivity, 77.27% the specificity, 91.94% the accuracy and 89.16% the positive predictive value. These results suggest that FTIR spectroscopy may be a potentially helpful tool for early diagnosis of PD.

引用

页数：4

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