Epigenetic reprogramming during tissue regeneration

被引:39
作者
Katsuyama, Tomonori [1 ]
Paro, Renato [1 ,2 ]
机构
[1] ETH, Dept Biosyst Sci & Engn, Zurich, Switzerland
[2] Univ Basel, Fac Sci, CH-4003 Basel, Switzerland
关键词
Epigenetic gene control; Polycomb group; Bivalent chromatin; Imaginal disc; Limb regeneration; POLYCOMB GROUP PROTEINS; PLURIPOTENT STEM-CELLS; VERTEBRATE LIMB REGENERATION; DROSOPHILA IMAGINAL DISCS; JNK SIGNALING PATHWAY; SONIC-HEDGEHOG SHH; DNA METHYLATION; HISTONE MODIFICATIONS; RESPONSE ELEMENTS; LEG REGENERATION;
D O I
10.1016/j.febslet.2011.05.010
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Epigenetic control of gene regulation is fundamental to the maintenance of cellular identities during all stages of metazoan life. Tissue regeneration involves cellular reprogramming processes, like dedifferentiation, re-differentiation, and trans-differentiation. Hence, in these processes epigenetic maintenance of gene expression programs requires a resetting through mechanisms that we are only beginning to understand. Here we summarize the current status of these studies, in particular regarding the role of epigenetic mechanisms of cellular reprogramming during tissue regeneration. (C) 2011 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
引用
收藏
页码:1617 / 1624
页数:8
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