Persistence with denosumab therapy in women affected by osteoporosis with fragility fractures: a multicenter observational real practice study in Italy

被引：38

作者：

Migliaccio, S. ^{[1
]}

Francomano, D. ^{[2
]}

Romagnoli, E. ^{[2
]}

Marocco, C. ^{[2
]}

Fornari, R. ^{[2
]}

Resmini, G. ^{[3
]}

Buffa, A. ^{[4
]}

Di Pietro, G. ^{[5
]}

Corvaglia, S. ^{[4
]}

Gimigliano, F. ^{[6
]}

Moretti, A. ^{[5
]}

de Sire, A. ^{[5
]}

Malavolta, N. ^{[4
]}

Lenzi, A. ^{[2
]}

Greco, E. A. ^{[2
]}

Iolascon, G. ^{[5
]}

机构：

[1] Univ Foro Italico, Sect Hlth Sci, Dept Movement Human & Hlth Sci, Piazza Lauro de Bosis,6, I-00135 Rome, Italy

[2] Sapienza Univ Rome, Sect Med Pathophysiol Endocrinol & Nutr, Dept Expt Med, Rome, Italy

[3] ASST Bergamo Ovest, Sect Orthopaed & Traumatol, Ctr Osteoporosis & Skeletal Metab Dis, Treviglio Caravaggio, Italy

[4] Univ Bologna, St Orsola Malpighi Hosp, Dept Program Rheumat Connect & Bone Metab Dis Man, Dept Med & Surg Sci, Bologna, Italy

[5] Univ Campania Luigi Vanvitelli, Dept Med & Surg Specialties & Dent, Via Crecchio 4, I-80138 Naples, Italy

[6] Univ Campania Luigi Vanvitelli, Dept Phys & Mental Hlth & Prevent Med, Naples, Italy

来源：

JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2017年 / 40卷 / 12期

关键词：

Denosumab; Osteoporosis; Persistence; Fracture; Observational study; POSTMENOPAUSAL WOMEN; BISPHOSPHONATE THERAPY; BONE TURNOVER; DRUG-THERAPY; ADHERENCE; MEDICATION; METAANALYSIS; ALENDRONATE; LIFE; BMD;

D O I：

10.1007/s40618-017-0701-3

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Persistence is commonly considered a key factor for the successful management of osteoporosis and fragility fractures. Denosumab is the first biologic agent developed for the treatment of osteoporosis with satisfying data regarding the persistence with this therapy. Aim The purpose of this multicenter observational real practice study was to evaluate the persistence with denosumab treatment in post-menopausal women affected by osteoporosis. Material/subjects and methods Women were recruited in four specialized centers for the management of osteoporosis in North, Center and South of Italy. We included women with a diagnosis of post-menopausal osteoporosis, aged > 50 years, able to obtain a prescription according to the Italian reimbursement criteria in force during the study period for anti-osteoporotic pharmacological treatment. They initiated a treatment with subcutaneous denosumab (Prolia (R)) 60 mg/every 6 months between November 2011 and May 2016. Women who had received aromatase inhibitors were excluded. Patients were assessed at baseline and every 6 months for all treatment length. Persistence data were evaluated for a total of 36 months. Results Eight hundred seventy women were enrolled; mean aged 70 years, with a mean body mass index of 24.8 +/- 4.1 kg/m(2). At the Dual-energy X-ray absorptiometry assessment, the mean lumbar spine T-score was -2.76 +/- 1.14 standard deviations (SD) and the mean femoral neck T-score was -2.49 +/- 0.80 SD. During the study, the total persistence was 91.4%. Total dropouts were 75 (8.6%), higher within the initial 6-month period of treatment. Conclusions Persistence to denosumab treatment in our observational real practice study was very high. These results suggest that factors such as frequency of visits, pharmacological schedule, and opportunity to call the doctor might play an important role in the persistence and adherence to treatment to obtain maximum therapeutic effect and avoid further fragility fractures.

引用

页码：1321 / 1326

页数：6

共 35 条

[1] Osteoporosis treatment: complexities and challenges [J].