Protection against SARS-CoV-2 Beta variant in mRNA-1273 vaccine-boosted nonhuman primates

被引：73

作者：

Corbett, Kizzmekia S. ^{[1
,8
]}

Gagne, Matthew ^{[1
]}

Wagner, Danielle A. ^{[1
]}

O' Connell, Sarah ^{[1
]}

Narpala, Sandeep R. ^{[1
]}

Flebbe, Dillon R. ^{[1
]}

Andrew, Shayne F. ^{[1
]}

Davis, Rachel L. ^{[1
]}

Flynn, Barbara ^{[1
]}

Johnston, Timothy S. ^{[1
]}

Stringham, Christopher D. ^{[1
,9
]}

Lai, Lilin ^{[2
]}

Valentin, Daniel ^{[3
]}

Van Ry, Alex ^{[3
]}

Flinchbaugh, Zackery ^{[3
]}

Werner, Anne P. ^{[1
]}

Moliva, Juan, I ^{[1
]}

Sriparna, Manjari ^{[1
,10
]}

O'Dell, Sijy ^{[1
]}

Schmidt, Stephen D. ^{[1
]}

Tucker, Courtney ^{[1
,11
]}

Choi, Angela ^{[4
]}

Koch, Matthew ^{[4
]}

Bock, Kevin W. ^{[5
]}

Minai, Mahnaz ^{[5
]}

Nagata, Bianca M. ^{[5
]}

Alvarado, Gabriela S. ^{[1
]}

Henry, Amy R. ^{[1
]}

Laboune, Farida ^{[1
]}

Schramm, Chaim A. ^{[1
]}

Zhang, Yi ^{[1
]}

Yang, Eun Sung ^{[1
]}

Wang, Lingshu ^{[1
]}

Choe, Misook ^{[1
]}

Boyoglu-Barnum, Seyhan ^{[1
]}

Wei, Shi ^{[1
]}

Lamb, Evan ^{[1
]}

Nurmukhambetova, Saule T. ^{[1
]}

Provost, Samantha J. ^{[1
]}

Donaldson, Mitzi M. ^{[1
]}

Marquez, Josue ^{[1
]}

Todd, John-Paul M. ^{[1
]}

Cook, Anthony ^{[3
]}

Dodson, Alan ^{[3
]}

Pekosz, Andrew ^{[6
]}

Boritz, Eli ^{[1
]}

Ploquin, Aurelie ^{[1
]}

Doria-Rose, Nicole ^{[1
]}

Pessaint, Laurent ^{[3
]}

Andersen, Hanne ^{[3
]}

机构：

[1] NIAID, Vaccine Res Ctr, NIH, Bethesda, MD 20892 USA

[2] Emory Univ, Ctr Childhood Infect & Vaccines Childrens Healthc, Emory Vaccine Ctr, Dept Pediat, Atlanta, GA 30322 USA

[3] BIOQUAL Inc, Rockville, MD 20850 USA

[4] Moderna Inc, Cambridge, MA 02139 USA

[5] NIAID, Infect Dis Pathogenesis Sect, NIH, Bethesda, MD 20892 USA

[6] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Microbiol & Immunol, Baltimore, MD 21205 USA

[7] NIAID, Biostat Res Branch, Div Clin Res, NIH, Bethesda, MD 20892 USA

[8] Harvard TH Chan Sch Publ Hlth, Dept Immunol & Infect Dis, Boston, MA 02115 USA

[9] Duke Univ, Sch Med, Med Scientist Training Program, Durham, NC 27705 USA

[10] Virginia Commonwealth Univ Med Coll Virginia, Richmond, VA 23223 USA

[11] NIAID, Div Intramural Res, NIH, Bethesda, MD 20892 USA

来源：

SCIENCE | 2021年 / 374卷 / 6573期

关键词：

SPIKE;

D O I：

10.1126/science.abl8912

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neutralizing antibody responses gradually wane against several variants of concern (VOCs) after vaccination with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine messenger RNA-1273 (mRNA-1273). We evaluated the immune responses in nonhuman primates that received a primary vaccination series of mRNA-1273 and were boosted about 6 months later with either homologous mRNA-1273 or heterologous mRNA-1273.b, which encompasses the spike sequence of the B.1.351 Beta variant. After boost, animals had increased neutralizing antibody responses across all VOCs, which was sustained for at least 8 weeks after boost. Nine weeks after boost, animals were challenged with the SARS-CoV-2 Beta variant. Viral replication was low to undetectable in bronchoalveolar lavage and significantly reduced in nasal swabs in all boosted animals, suggesting that booster vaccinations may be required to sustain immunity and protection.

引用

页码：1343 / +

页数：29

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