Managing a Case of Extensively Drug-Resistant (XDR) Pulmonary Tuberculosis in Singapore

被引：0

作者：

Phua, Chee Kiang ^{[1
]}

Chee, Cynthia B. E. ^{[1
]}

Chua, Angeline P. G. ^{[1
]}

Gan, Suay Hong ^{[1
]}

Ahmed, Aneez D. B. ^{[2
]}

Wang, Yee Tang ^{[1
]}

机构：

[1] Tan Tock Seng Hosp, TB Control Unit, Singapore 308087, Singapore

[2] Tan Tock Seng Hosp, Dept Gen Surg Thorac, Singapore 308087, Singapore

来源：

ANNALS ACADEMY OF MEDICINE SINGAPORE | 2011年 / 40卷 / 03期

关键词：

Directly observed therapy; Multidrug-resistant; Mycobacteria; MULTIDRUG-RESISTANT; SURGERY;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Introduction: Extensively drug-resistant tuberculosis (XDR-TB) is an emerging global health risk. We present the first case report of XDR-TB in Singapore. Clinical Picture: A 41-year-old Indonesian lady with previously treated pulmonary tuberculosis presented with chronic cough. Her sputum was strongly acid-fast bacilli positive and grew Mycobacterium tuberculosis complex resistant to first and second-line TB medications. Treatment: She received 5 months of intensive multidrug treatment without sputum smear conversion. She then underwent resection of the diseased lung. The total cost incurred amounted to over S$100,000. Outcome: She achieved sputum smear/culture conversion post-surgery, but will require further medical therapy for at least 18 months. Conclusion: XDR-TB is poorly responsive to therapy and extremely expensive to manage. Its prevention by strict compliance to therapy is paramount. Ann Acad Med Singapore 40;3:132-5

引用

页码：132 / 135

页数：4

共 14 条

[1] [Anonymous], 2006, Morbidity and Mortality Weekly Report, V55, P1176
[2] [Anonymous], 2010, Multidrug and extensively drug-resistant TB(M/XDR-TB): 2010 Global Report on Surveillance and Response
[3] Centers for Disease Control and Prevention (CDC), 2006, MMWR Morb Mortal Wkly Rep, V55, P301
[4] Chee C. B. E., 2006, SMJ Singapore Medical Journal, V47, P529
[5] Adjunctive resectional lung surgery for extensively drug-resistant tuberculosis
Dravniece, G.
Cain, K. P.
Holtz, T. H.
Riekstina, V.
Leimane, V.
Zaleskis, R.
[J]. EUROPEAN RESPIRATORY JOURNAL, 2009, 34 (01) : 180 - 183
[6] Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis
Gandhi, Neel R.
Nunn, Paul
Dheda, Keertan
Schaaf, H. Simon
Zignol, Matteo
van Soolingen, Dick
Jensen, Paul
Bayona, Jaime
[J]. LANCET, 2010, 375 (9728) : 1830 - 1843
[7] Extensively drug-resistant tuberculosis
Jassal, Mandeep
Bishai, William R.
[J]. LANCET INFECTIOUS DISEASES, 2009, 9 (01) : 19 - 30
[8] Surgical Treatment for Multidrug-Resistant and Extensive Drug-Resistant Tuberculosis
Kang, Min-Woong
Kim, Hong Kwan
Choi, Yong Soo
Kim, Kwhanmien
Shim, Young Mog
Koh, Won-Jung
Kim, Jhingook
[J]. ANNALS OF THORACIC SURGERY, 2010, 89 (05) : 1597 - 1602
[9] Ministry of Health Singapore, 2009, COMM DIS SURV SING 2
[10] Ministry of Health Singapore, 2007, MINISTRY HLTH EPIDEM, V33, P50

← 1 2 →