Cerebral tuber count and its impact on mental outcome of patients with tuberous sclerosis complex

被引：55

作者：

Kaczorowska, Magdalena ^{[1
]}

Jurkiewicz, Elzbieta ^{[2
]}

Domanska-Pakiela, Dorota ^{[1
]}

Syczewska, Malgorzata ^{[3
]}

Lojszczyk, Barbara ^{[4
]}

Chmielewski, Dariusz ^{[1
]}

Kotulska, Katarzyna ^{[1
]}

Kuczynski, Dariusz ^{[1
]}

Kmiec, Tomasz ^{[1
]}

Dunin-Wasowicz, Dorota ^{[1
]}

Kasprzyk-Obara, Jolanta ^{[1
]}

Jozwiak, Sergiusz ^{[1
]}

机构：

[1] Childrens Mem Hlth Inst, Dept Neurol, Warsaw, Poland

[2] Childrens Mem Hlth Inst, Dept Radiol, MR Unit, Warsaw, Poland

[3] Childrens Mem Hlth Inst, Dept Pediat Rehabil, Warsaw, Poland

[4] Childrens Mem Hlth Inst, Dept Psychol, Warsaw, Poland

来源：

EPILEPSIA | 2011年 / 52卷 / 01期

关键词：

TSC; Epilepsy; Infantile spasms; Tuber count; Outcome; CONSENSUS CONFERENCE; MRI FINDINGS; EPILEPSY; SEIZURE; IMPAIRMENT; CHILDREN;

D O I：

10.1111/j.1528-1167.2010.02892.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

P>Purpose: The aim of the study was to reveal the relationships between the tuber count of the brain found in patients with tuberous sclerosis complex (TSC) and their cognitive outcome. Methods: A single-center, retrospective analysis was performed of patients with documented TSC seen from 1988 to 2010 at the Children's Memorial Health Institute, Warsaw, Poland. Key Findings: Sixty-two patients were analyzed, and there was a significant correlation between younger age at the first seizure and developmental delay. The patients who did not develop seizures had normal development, despite some presenting with higher tuber load than those with seizures. There was a statistically significant negative correlation between the number of tubers within the right temporal lobe and cognition. Significance: Our findings confirm our hypothesis that the cognitive outcome in TSC is more dependent on the age of the seizure onset rather than on the tuber count.

引用

页码：22 / 27

页数：6

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