Whole-body kinetics and dosimetry of cis-4-[18F]fluoro-L-proline

被引：16
作者：
Börner, AR
Langen, KJ
Herzog, H
Hamacher, K
Müller-Mattheis, V
Schmitz, T
Ackermann, R
Coenen, HH
机构：
[1] Res Ctr Julich, Inst Med, D-52425 Julich, Germany
[2] Univ Dusseldorf, Clin Nucl Med, D-4000 Dusseldorf, Germany
[3] Res Ctr Julich, Inst Nucl Chem, Julich, Germany
[4] Univ Dusseldorf, Urol Klin, D-4000 Dusseldorf, Germany
来源：
NUCLEAR MEDICINE AND BIOLOGY | 2001年 / 28卷 / 03期
关键词：
cis-4-[F-18]fluoro-L-proline (cis-FPro); dosimetry; whole-body distribution; amino acids; PET;
D O I：
10.1016/S0969-8051(00)00198-0
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
The whole-body distribution of 4-cis[F-18]fluoro-L-proline (cis-FPro) was studied in six patients with urological tumors by PET. Based on the IMEDOSE and MIRDOSE procedures radiation absorbed doses were estimated from whole-body PET scans acquired at 1 and 3-5 h after i.v. injection of 400 MBq cis-FPro. Cis-FPro showed high retention in the renal cortex and a slight uptake in liver and pancreas. Urinary excretion ranged from 12 to 19% at 5 h p.i. Highest absorbed doses were found for the urinary bladder wall and the kidneys (44.1/44.0 mu Gy/MBq). The effective dose according to ICRP 60 was 15.1 mu Sv/MBq for adults. This leads to an effective dose of 6.0 mSv in a PET study using 400 MBq cis-FPro. (C) 2001 Elsevier Science Inc. All rights reserved.
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收藏
页码：287 / 292
页数：6
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