Single-cell chromatin state analysis with Signac

被引:743
作者
Stuart, Tim [1 ,2 ]
Srivastava, Avi [1 ,2 ]
Madad, Shaista [1 ,2 ]
Lareau, Caleb A. [3 ]
Satija, Rahul [1 ,2 ]
机构
[1] New York Genome Ctr, New York, NY 10013 USA
[2] NYU, Ctr Genom & Syst Biol, New York, NY 10013 USA
[3] Stanford Univ, Dept Genet & Pathol, Stanford, CA 94305 USA
基金
美国国家卫生研究院;
关键词
ACCESSIBILITY; DNA;
D O I
10.1038/s41592-021-01282-5
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The recent development of experimental methods for measuring chromatin state at single-cell resolution has created a need for computational tools capable of analyzing these datasets. Here we developed Signac, a comprehensive toolkit for the analysis of single-cell chromatin data. Signac enables an end-to-end analysis of single-cell chromatin data, including peak calling, quantification, quality control, dimension reduction, clustering, integration with single-cell gene expression datasets, DNA motif analysis and interactive visualization. Through its seamless compatibility with the Seurat package, Signac facilitates the analysis of diverse multimodal single-cell chromatin data, including datasets that co-assay DNA accessibility with gene expression, protein abundance and mitochondrial genotype. We demonstrate scaling of the Signac framework to analyze datasets containing over 700,000 cells. The Signac framework enables the end-to-end analysis of single-cell chromatin data and interoperability with the Seurat package for multimodal analysis.
引用
收藏
页码:1333 / +
页数:15
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