Requirements for selection of conventional and innate T lymphocyte lineages

被引：81

作者：

Horai, Reiko ^{[1
]}

Mueller, Kristen L. ^{[1
]}

Handon, Robin A. ^{[1
]}

Cannons, Jennifer L. ^{[1
]}

Anderson, Stacie M. ^{[1
]}

Kirby, Martha R. ^{[1
]}

Schwartzberg, Pamela L. ^{[1
]}

机构：

[1] NIH, NHGRI, Bethesda, MD 20892 USA

来源：

IMMUNITY | 2007年 / 27卷 / 05期

关键词：

D O I：

10.1016/j.immuni.2007.09.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Mice deficient in the Tec kinase Itk develop a large population of CD8(+) T cells with properties, including expression of memory markers, rapid production of cytokines, and dependence on Interleukin-15, resembling NKT and other innate T cell lineages. Like NKT cells, these CD8(+) T cells can be selected on hematopoietic cells' We demonstrate that these CD8(+) T cell phenotypes resulted from selection on hematopoietic cells-forcing selection on the thymic stroma reduced the number and innate phenotypes of mature ltk-deficient CD8(+) T cells. We further show that, similar to NKT cells, selection of innate-type CD8(+) T cells in Itk(-/-) mice required the adaptor SAP. Acquisition of their innate characteristics, however, required CD28. Our results suggest that SAP and Itk reciprocally regulate selection of innate and conventional CD8(+) T cells on hematopoietic cells and thymic epithelium, respectively, whereas CD28 regulates development of innate phenotypes resulting from selection on hematopoietic cells.

引用

页码：775 / 785

页数：11

共 57 条

[1] CD28-B7 interactions function to co-stimulate clonal deletion of double-positive thymocytes [J].