Platelet-rich fibrin may reduce the risk of delayed recovery in tooth-extracted patients undergoing oral bisphosphonate therapy: a trial study

被引：43
作者：
Asaka, Takuya [1 ]
Ohga, Noritaka [1 ]
Yamazaki, Yutaka [2 ]
Sato, Jun [1 ]
Satoh, Chiharu [1 ]
Kitagawa, Yoshimasa [1 ]
机构：
[1] Hokkaido Univ, Grad Sch Dent Med, Dept Oral Diag & Med, Kita Ku, Kita 13 Nishi 7, Sapporo, Hokkaido 0608586, Japan
[2] Hokkaido Univ, Dept Gerodontol, Grad Sch Dent Med, Sapporo, Hokkaido, Japan
来源：
CLINICAL ORAL INVESTIGATIONS | 2017年 / 21卷 / 07期
关键词：
PRF; Oral bisphosphonates; Tooth extraction; Epithelization; MRONJ; OSTEONECROSIS; JAW; PLASMA; PRF;
D O I：
10.1007/s00784-016-2004-z
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The aim of the present study was to evaluate the effectiveness of platelet-rich fibrin (PRF) as a wound-healing accelerator in patients undergoing oral bisphosphonate therapy and requiring tooth extractions. A total of 102 patients were divided into a PRF group and control group. The patients received oral bisphosphonate therapy for osteoporosis for an average of 32 months. Blood was collected and PRF was introduced into the socket of the PRF group only. Monitoring of mucosal healing was conducted for 3 months in both groups, and radiographic evaluation in the sockets was performed in the PRF group. Delayed recovery was defined as exposed bone and vulnerable granulation tissue without epithelization after 4 weeks and resolving by 8 weeks. There were no intraoperative complications, and none of the patients exhibited onset of medication-related osteonecrosis of the jaw (MRONJ). Delayed recovery was observed in 9 out of 73 control patients (12%), whereas 29 PRF patients exhibited complete epithelialization of the socket within 1 month. The prevalence of delayed recovery was significantly higher in the control group than the PRF group (P < 0.05). Multivariate logistic regression analysis revealed that risk factors and use of PRF were independent significant factors to relate to delayed recovery (P = 0.02). Early epithelization was confirmed in all PRF patients. Thus, PRF may reduce the risk of delayed recovery in patients undergoing oral bisphosphonate therapy. PRF may be useful in preventing MRONJ in patients receiving oral bisphosphonate (BP).
引用
收藏
页码：2165 / 2172
页数：8
相关论文
共 25 条
  • [1] Perspectives and challenges in regenerative medicine using plasma rich in growth factors
    Anitua, Eduardo
    Alkhraisat, Mohammad H.
    Orive, Gorka
    [J]. JOURNAL OF CONTROLLED RELEASE, 2012, 157 (01) : 29 - 38
  • [2] Use of platelet-rich plasma in the treatment of bisphosphonate-related osteonecrosis of the jaw
    Bocanegra-Perez, S.
    Vicente-Barrero, M.
    Knezevic, M.
    Castellano-Navarro, J. M.
    Rodriguez-Bocanegra, E.
    Rodriguez-Millares, J.
    Perez-Plasencia, D.
    Ramos-Macias, A.
    [J]. INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2012, 41 (11) : 1410 - 1415
  • [3] Osteonecrosis of the jaw in patients with multiple myeloma treated with zoledronic acid
    Cetiner, Sedat
    Sucak, Gulsan Turkoz
    Kahraman, Sevil Altundag
    Aki, Sahika Zeynep
    Kocakahyaoglu, Benay
    Gultekin, Sibel Elif
    Cetiner, Mustafa
    Haznedar, Rauf
    [J]. JOURNAL OF BONE AND MINERAL METABOLISM, 2009, 27 (04) : 435 - 443
  • [4] Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part V: Histologic evaluations of PRF effects on bone allograft maturation in sinus lift
    Choukroun, J
    Diss, A
    Simonpieri, A
    Girard, MO
    Schoeffler, C
    Dohan, SL
    Dohan, AJJ
    Mouhyi, J
    Dohan, DM
    [J]. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 2006, 101 (03): : 299 - 303
  • [5] Bisphosphonate-Related Osteonecrosis of the Jaws-An Initial Case Series Report of Treatment Combining Partial Bone Resection and Autologous Platelet-Rich Plasma
    Curi, Marcos Martins
    Issa Cossolin, Giuliano Saraceni
    Koga, Daniel Henrique
    Zardetto, Cristina
    Christianini, Silmara
    Feher, Olavo
    Cardoso, Camila Lopes
    dos Santos, Marcelo Oliveira
    [J]. JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2011, 69 (09) : 2465 - 2472
  • [6] Autologous platelet concentrates for bisphosphonate-related osteonecrosis of the jaw treatment and prevention. A systematic review of the literature
    Del Fabbro, Massimo
    Gallesio, Giorgia
    Mozzati, Marco
    [J]. EUROPEAN JOURNAL OF CANCER, 2015, 51 (01) : 62 - 74
  • [7] Dohan David M, 2006, Oral Surg Oral Med Oral Pathol Oral Radiol Endod, V101, pe45, DOI 10.1016/j.tripleo.2005.07.009
  • [8] Dohan EDM, 1998, TRENDS BIOTECHNOL, V27, P158
  • [9] Slow release of growth factors and thrombospondin-1 in Choukroun's platelet-rich fibrin (PRF): a gold standard to achieve for all surgical platelet concentrates technologies
    Ehrenfest, David M. Dohan
    de Peppo, Giuseppe M.
    Doglioli, Pierre
    Sammartino, Gilberto
    [J]. GROWTH FACTORS, 2009, 27 (01) : 63 - 69
  • [10] A comparative study of platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) on the effect of proliferation and differentiation of rat osteoblasts in vitro
    He, Ling
    Lin, Ye
    Hu, Xiulian
    Zhang, Yu
    Wu, Hui
    [J]. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY, 2009, 108 (05): : 707 - 713
123