Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss

被引：124

作者：

Al-Mrabeh, Ahmad ^{[1
]}

Zhyzhneuskaya, Sviatlana V. ^{[1
]}

Peters, Carl ^{[1
]}

Barnes, Alison C. ^{[2
]}

Melhem, Shaden ^{[1
]}

Jesuthasan, Aaron ^{[3
]}

Aribisala, Benjamin ^{[4
]}

Hollingsworth, Kieren G. ^{[1
]}

Lietz, Georg ^{[2
]}

Mathers, John C. ^{[2
]}

Sattar, Naveed ^{[5
]}

Lean, Michael E. J. ^{[6
]}

Taylor, Roy ^{[1
]}

机构：

[1] Newcastle Univ, Translat & Clin Res Inst, Magnet Resonance Ctr, Newcastle Upon Tyne NE4 5PL, Tyne & Wear, England

[2] Newcastle Univ, Populat & Hlth Sci Inst, Human Nutr Res Ctr, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[3] Newcastle Univ, Fac Med Sci, Sch Med Educ, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[4] Lagos State Univ, Comp Sci Dept, PMB 0001, Lagos, Nigeria

[5] Univ Glasgow, Inst Cardiovasc & Med Sci, Glasgow G12 8TA, Lanark, Scotland

[6] Univ Glasgow, Sch Med Dent & Nursing, Glasgow G31 2ER, Lanark, Scotland

来源：

CELL METABOLISM | 2020年 / 31卷 / 02期

基金：

英国医学研究理事会;

关键词：

DE-NOVO LIPOGENESIS; BETA-CELL DEDIFFERENTIATION; MUSCLE INSULIN-RESISTANCE; LOW-CALORIE DIET; FATTY-ACIDS; ECTOPIC FAT; LIVER; STEATOSIS; PATHOGENESIS; MECHANISMS;

D O I：

10.1016/j.cmet.2019.11.018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The role of hepatic lipoprotein metabolism in diet-induced remission of type 2 diabetes is currently unclear. Here, we determined the contributions of hepatic VLDL1-triglyceride production rate and VLDL1-palmitic acid content to changes in intra-pancreatic fat and return of first phase insulin response in a subgroup of the Diabetes Remission Clinical Trial. Liver fat, VLDL1-triglyceride production, and intra-pancreatic fat decreased after weight loss and remained normalized after 24 months of remission. First-phase insulin response remained increased only in those maintaining diabetes remission. Compared with those in remission at 24 months, individuals who relapsed after initial remission had a greater rise in the content of VLDL1-triglyceride and VLDL1-palmitic acid, re-accumulated intrapancreatic fat, and lost first-phase response by 24 months. Thus, we observed temporal relationships between VLDL1-triglyceride production, hepatic palmitic acid flux, intra-pancreatic fat, and 13-cell function. Weight-related disordered fat metabolism appears to drive development and reversal of type 2 diabetes.

引用

页码：233 / +

页数：21

共 77 条

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