N-(2,5-Dimethoxyphenyl)-N′-(4-hydroxyphenethyl)urea

被引:0
作者
Choi, Hyeong [1 ]
Han, Byung Hee [1 ]
Shim, Yong Suk [1 ]
Kang, Sung Kwon [1 ]
Sung, Chang Keun [2 ]
机构
[1] Chungnam Natl Univ, Dept Chem, Taejon 305764, South Korea
[2] Chungnam Natl Univ, Dept Food Sci & Technol, Taejon 305764, South Korea
来源
ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE | 2010年 / 66卷
基金
新加坡国家研究基金会;
关键词
SLOW-BINDING INHIBITOR; TYROSINASE INHIBITORS; KOJIC ACID; CELLS;
D O I
10.1107/S1600536810038535
中图分类号
O7 [晶体学];
学科分类号
0702 ; 070205 ; 0703 ; 080501 ;
摘要
In the title compound, C(17)H(20)N(2)O(4), the 2,5-dimethoxyphenyl unit is almost planar, with an r.m.s. deviation of 0.015 angstrom. The dihedral angle between the 2,5-dimethoxyphenyl ring and the urea plane is 20.95 (8)degrees. The H atoms of the urea NH groups are positioned syn to each other. The molecular structure is stabilized by a short intramolecular N-H center dot center dot center dot O hydrogen bond. In the crystal, intermolecular N-H center dot center dot center dot O and O-H center dot center dot center dot O hydrogen bonds link the molecules into a three-dimensional network.
引用
收藏
页码:O2705 / U1634
页数:11
相关论文
共 50 条
[31]   Novel potent 2,5-pyrrolidinedione peptidomimetics as aminopeptidase N inhibitors. Design, synthesis and activity evaluation [J].
Li, Qianbin ;
Fang, Hao ;
Wang, Xuejian ;
Hu, Gaoyun ;
Wang, Qiang ;
Xu, Wenfang .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 22 (02) :850-853
[32]   Ability of 2-Chloro-N-(1-(3,4-dimethoxyphenyl)propan-2-yl)-2-phenylacetamide to Stimulate Endogenous Nitric Oxide Synthesis [J].
Gledacheva, Vera ;
Pencheva, Mina ;
Nikolova, Stoyanka ;
Stefanova, Iliyana .
APPLIED SCIENCES-BASEL, 2022, 12 (09)
[33]   Pathway of oral absorption of heparin with sodium N-[8-(2-hydroxybenzoyl)amino]caprylate [J].
Malkov, D ;
Wang, HZ ;
Dinh, S ;
Gomez-Orellana, I .
PHARMACEUTICAL RESEARCH, 2002, 19 (08) :1180-1184
[34]   Discovery of Substituted N-(6-Chloro-3-cyano-4-phenyl-4H-chromen-2-yl)-2-(4-chloro-phenoxy)-acetamide for Biphasic Anti-cancer and Anticonvulsant Activities [J].
Chauhan, Divya ;
Hashim, Syad Riaz ;
Rani, Prinka ;
Kumar, Sushil ;
Shrimal, Navratan ;
Shastri, Divya ;
Raj, Vinit .
MEDICINAL CHEMISTRY, 2021, 17 (03) :203-215
[35]   N-{N-[2-(3,5-Difluorophenyl)acetyl]-(S)-alanyl}-(S)-phenylglycine tert-butyl ester (DAPT): an inhibitor of γ-secretase, revealing fine electronic and hydrogen-bonding features [J].
Czerwinski, Andrzej ;
Valenzuela, Francisco ;
Afonine, Pavel ;
Dauter, Miroslawa ;
Dauter, Zbigniew .
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 2010, 66 :O585-O588
[36]   One-pot synthesis and biological evaluation of N-(aminosulfonyl)-4-podophyllotoxin carbamates as potential anticancer agents [J].
Xu, Xiao-Hui ;
Guan, Xiao-Wen ;
Feng, Shi-Liang ;
Ma, You-Zhen ;
Chen, Shi-Wu ;
Hui, Ling .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (13) :2890-2894
[37]   The arylpiperazine derivatives N-(4-cyanophenylmethyl)4-( 2-diphenyl)-1-piperazinehexanamide and N-benzyl-4( 2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling [J].
Atanes, Patricio ;
Lacivita, Enza ;
Rodriguez, Javier ;
Brea, Jose ;
Burgueno, Javier ;
Miguel Vela, Jose ;
Isabel Cadavid, Maria ;
Isabel Loza, Maria ;
Leopoldo, Marcello ;
Castro, Marian .
PHARMACOLOGY RESEARCH & PERSPECTIVES, 2013, 1 (02)
[38]   N-(2-formylphenyl)-4-methylbenzenesulfonamide: A simple endoplasmic reticulum-targetable probe for the ratiometric fluorescent detection of hydrazine in environmental and biological systems [J].
Yang, Ning-Xia ;
Xiong, Bao-Xue ;
Zhang, Yi-Ting ;
Wu, Jia-Fan ;
Liu, Bo-Han ;
Wu, Wei-Na ;
Han, Xue-Feng ;
Bian, Lin-Yan ;
Wang, Yuan .
MICROCHEMICAL JOURNAL, 2024, 205
[39]   N-(2-Hydroxypropyl)methacrylamide Copolymer-Drug Conjugates for Combination Chemotherapy of Acute Myeloid Leukemia [J].
Zhang, Rui ;
Yang, Jiyuan ;
Zhou, Yan ;
Shami, Paul J. ;
Kopecek, Jindrich .
MACROMOLECULAR BIOSCIENCE, 2016, 16 (01) :121-128
[40]   Effect of H4R Antagonist N-(2-Aminoethyl)-5-Chloro-1H-Indole-2-Carboxamide (Compound A) in a Mouse Model of Allergic Asthma [J].
Nagarajan, Gomathi ;
Thangam, Elden Berla .
IMMUNOLOGICAL INVESTIGATIONS, 2021, 50 (2-3) :125-138