High-Throughput Quantitation of Neonicotinoids in Lyophilized Surface Water by LC-APCI-MS/MS

被引:12
作者
Morrison, Lucas M. [1 ,2 ]
Renaud, Justin B. [1 ]
Sabourin, Lyne [1 ]
Sumarah, Mark W. [1 ,2 ]
Yeung, Ken K. C. [2 ,3 ]
Lapen, David R. [4 ]
机构
[1] Agr & Agri Food Canada, London Res & Dev Ctr, London, ON N5V 4T3, Canada
[2] Univ Western Ontario, Dept Chem, London, ON N6A 5B7, Canada
[3] Univ Western Ontario, Dept Biochem, London, ON N6A 5C1, Canada
[4] Agr & Agri Food Canada, Ottawa Res & Dev Ctr, Ottawa, ON K1A 0C6, Canada
关键词
MASS-SPECTROMETRY ANALYSIS; LIQUID-CHROMATOGRAPHY; DRINKING-WATER; INSECTICIDES; EXTRACTION; PESTICIDES; ANTIBIOTICS; RESIDUES; FATE; MS;
D O I
10.5740/jaoacint.17-0486
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Background: Neonicotinoids are among the most widely used insecticides. Recently, there has been concern associated with unintended adverse effects on honeybees and aquatic invertebrates at low parts-per-trillion levels. Objective: There is a need for LC-MS/MS methods that are capable of high-throughput measurements of the most widely used neonicotinoids at environmentally relevant concentrations in surface water. Methods: This method allows for quantitation of acetamiprid, clothianidin, imidacloprid, dinotefuran, nitenpyram, thiacloprid, and thiamethoxam in surface water. Deuterated internal standards are added to 20 mL environmental samples, which are concentrated by lyophilisation and reconstituted with methanol followed by acetonitrile. Results: A large variation of mean recovery efficiencies across five different surface water sampling sites within this study was observed, ranging from 45 to 74%. This demonstrated the need for labelled internal standards to compensate for these differences. Atmospheric pressure chemical ionization (APCI) performed better than electrospray ionization (ESI) with limited matrix suppression, achieving 71-110% of the laboratory fortified blank signal. Neonicotinoids were resolved on a C18 column using a 5 min LC method, in which MQL ranged between 0.93 and 4.88 ng/L. Conclusions: This method enables cost effective, accurate, and reproducible monitoring of these pesticides in the aquatic environment. Highlights: Lyophilization is used for high throughput concentration of neonicotinoids in surface water. Variations in matrix effects between samples was greatly reduced by using APCI compared with ESI. Clothianidin and thiamethoxam were detected in all samples with levels ranging from below method quantitation limit to 65 ng/L.
引用
收藏
页码:1940 / 1947
页数:8
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