Cu-ATSM: A radiopharmaceutical for the PET imaging of hypoxia

被引：203
作者：
Vavere, Amy L.
Lewis, Jason S.
机构：
[1] Washington Univ, Sch Med, Dept Radiol, Mallinckrodt Inst Radiol, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Alvin J Siteman Canc Ctr, St Louis, MO 63110 USA
来源：
DALTON TRANSACTIONS | 2007年 / 43期
关键词：
D O I：
10.1039/b705989b
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Copper( II)-diacetyl-bis( N-4-methylthiosemicarbazone), Cu-ATSM, labeled with a positron emitting isotope of copper ( Cu-60, Cu-61, Cu-62 or Cu-64) has been shown, in vitro and in vivo, to be selective for hypoxic tissue. In silico studies have explored the mechanism of its hypoxia selectivity, and clinical studies with this agent have shown non-invasive imaging data that is predictive of a cancer patients' response to conventional therapy. This Perspective discusses the evolution of Cu-ATSM, how its selectivity can be improved upon, and where this metal-ligand platform could be taken in the future.
引用
收藏
页码：4893 / 4902
页数：10
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