Preliminary evidence of widespread morphological variations of the brain in dyslexia

被引：157
作者：
Brown, WE
Eliez, S
Menon, V
Rumsey, JM
White, CD
Reiss, AL
机构：
[1] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford Psychiat Neuroimaging Lab, Stanford, CA 94305 USA
[2] NIMH, Clin Neurosci Branch, Rockville, MD 20857 USA
来源：
NEUROLOGY | 2001年 / 56卷 / 06期
关键词：
D O I：
10.1212/WNL.56.6.781
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
The MR images of 16 men with dyslexia and 14 control subjects were compared using a voxel-based analysis. Evidence of decreases in gray matter in dyslexic subjects, most notably in the left temporal lobe and bilaterally in the temporoparietooccipital juncture, but also in the frontal lobe, caudate, thalamus, and cerebellum, was found. Widely distributed morphologic differences affecting several brain regions may contribute to the deficits associated with dyslexia.
引用
收藏
页码：781 / 783
页数：3
相关论文
共 11 条
  • [1] Voxel-based morphometry - The methods
    Ashburner, J
    Friston, KJ
    [J]. NEUROIMAGE, 2000, 11 (06) : 805 - 821
  • [2] Abnormal processing of visual motion In dyslexia revealed by functional brain imaging
    Eden, GF
    VanMeter, JW
    Rumsey, JM
    Maisog, JM
    Woods, RP
    Zeffiro, TA
    [J]. NATURE, 1996, 382 (6586) : 66 - 69
  • [3] Eliez S, 2000, J CHILD PSYCHOL PSYC, V41, P637
  • [4] Fulbright RK, 1999, AM J NEURORADIOL, V20, P1925
  • [5] fMRI during word processing in dyslexic and normal reading children
    Georgiewa, P
    Rzanny, R
    Hopf, JM
    Knab, R
    Glauche, V
    Kaiser, WA
    Blanz, B
    [J]. NEUROREPORT, 1999, 10 (16) : 3459 - 3465
  • [6] Deficit of temporal auditory processing in dyslexic adults
    Hari, R
    Kiesila, P
    [J]. NEUROSCIENCE LETTERS, 1996, 205 (02) : 138 - 140
  • [7] ANOMALOUS CEREBRAL STRUCTURE IN DYSLEXIA REVEALED WITH MAGNETIC-RESONANCE-IMAGING
    LEONARD, CM
    VOELLER, KKS
    LOMBARDINO, LJ
    MORRIS, MK
    HYND, GW
    ALEXANDER, AW
    ANDERSEN, HG
    GAROFALAKIS, M
    HONEYMAN, JC
    MAO, JT
    AGEE, OF
    STAAB, EV
    [J]. ARCHIVES OF NEUROLOGY, 1993, 50 (05) : 461 - 469
  • [8] Diagnostic and Statistical Manual of Mental Disorders
    Mittal, Vijay A.
    Walker, Elaine F.
    [J]. PSYCHIATRY RESEARCH, 2011, 189 (01) : 158 - 159
  • [9] FUNCTIONAL-ANATOMY OF THE BASAL GANGLIA .1. THE CORTICO-BASAL GANGLIA-THALAMO-CORTICAL LOOP
    PARENT, A
    HAZRATI, LN
    [J]. BRAIN RESEARCH REVIEWS, 1995, 20 (01) : 91 - 127
  • [10] A positron emission tomographic study of impaired word recognition and phonological processing in dyslexic men
    Rumsey, JM
    Nace, K
    Donohue, B
    Wise, D
    Maisog, JM
    Andreason, P
    [J]. ARCHIVES OF NEUROLOGY, 1997, 54 (05) : 562 - 573
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