REPROGRAMMING OF SOMATIC CELLS TO PLURIPOTENCY

被引：0

作者：

Nakagawa, Masato ^{[1
]}

Yamanaka, Shinya ^{[1
]}

机构：

[1] Kyoto Univ, Ctr iPS Res & Applicat, Sakyo Ku, Kyoto 6068507, Japan

来源：

CELL BIOLOGY OF STEM CELLS | 2010年 / 695卷

关键词：

STEM-CELLS; TUMOR-SUPPRESSOR; MOUSE; GENERATION; FIBROBLASTS; MYC; CIRCUITRY; NUCLEI; NANOG; LINES;

D O I：

暂无

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Reprogramming of somatic cells into pluripotent stem cells has been achieved by introducing four transcription factors, Sox2, Oct3/4, Klf4 and c-Myc, in 2006. These induced pluripotent stem (iPS) cells have raised hopes for a new era of regenerative medicine because they can avoid the ethical problems and innate immune rejection associated with embryonic stem cells. However, the underlying molecular mechanism of reprogramming still remains unclear. In this chapter, we look back at the history of reprogramming research ranging from amphibian to mammalian cells and discuss our recent understanding of the molecular mechanisms of reprogramming and the possibility of utilizing reprogrammed cells for regenerative medicine.

引用

页码：215 / 224

页数：10

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