Diffusive dynamics of the reaction coordinate for protein folding funnels

被引：458

作者：

Socci, ND ^{[1
]}

Onuchic, JN ^{[1
]}

Wolynes, PG ^{[1
]}

机构：

[1] UNIV ILLINOIS,SCH CHEM SCI,URBANA,IL 61801

来源：

JOURNAL OF CHEMICAL PHYSICS | 1996年 / 104卷 / 15期

关键词：

D O I：

10.1063/1.471317

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The quantitative description of model protein folding kinetics using a diffusive collective reaction coordinate is examined. Direct folding kinetics, diffusional coefficients and free energy profiles are determined from Monte Carlo simulations of a 27-mer, 3 letter code lattice model, which corresponds roughly to a small helical protein. Analytic folding calculations, using simple diffusive rate theory, agree extremely well with the full simulation results. Folding in this system is best seen as a diffusive, funnel-like process. (C) 1996 American Institute of Physics.

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页码：5860 / 5868

页数：9

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