Isolation and structure elucidation of chlorofusin, a novel p53-MDM2 antagonist from a Fusarium sp.

被引：146

作者：

Duncan, SJ ^{[1
]}

Grüschow, S ^{[1
]}

Williams, DH ^{[1
]}

McNicholas, C ^{[1
]}

Purewal, R ^{[1
]}

Hajek, M ^{[1
]}

Gerlitz, M ^{[1
]}

Martin, S ^{[1
]}

Wrigley, SK ^{[1
]}

Moore, M ^{[1
]}

机构：

[1] Univ Cambridge, Cambridge Ctr Mol Recognit, Chem Lab, Cambridge CB2 1EW, England

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2001年 / 123卷 / 04期

关键词：

D O I：

10.1021/ja002940p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Wild-type p53 plays a crucial role in the prevention of cancer. Since dysfunction of p53 can be caused by increased levels of the protein MDM2, small molecules which antagonize the interaction between these two-proteins have-potential in cancer therapy. The discovery and structure determination of a fungal metabolite, chlorofusin, which antagonizes the p53/MDM2 interaction are reported.

引用

页码：554 / 560

页数：7

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