Familial invasive and in situ squamous cell carcinoma of the skin

被引:15
作者
Hemminki, K
Zhang, H
Czene, K
机构
[1] Karolinska Inst, Dept Biosci Novum, S-14157 Huddinge, Sweden
[2] German Canc Res Ctr, Div Mol Genet Epidemiol, Heidelberg, Germany
关键词
multiple skin cancer; multiple skin cancers; Bowen's disease; in situ carcinoma;
D O I
10.1038/sj.bjc.6600909
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
We used the updated nation-wide Swedish Family-Cancer Database to examine familial risks in data from 1961 to 1998 on 1252 invasive and 2474 in situ squamous cell carcinoma (SCC) of the skin among offspring, and over 10 times more among parents. In 259 families a parent and an offspring had skin SCC. The familial standardised incidence ratios (SIRs) were 2.72 for invasive and 2.40 for in situ skin cancers in offspring. Multiple skin cancers in parents were associated with increased SIRs for invasive SCC in offspring, being 2.55 for one and up to 14.93 for two invasive and two in situ cancers in parents; the corresponding in situ SCC risks were 2.28 and 7.49. The population attributable fraction for any familial skin SCC, invasive or in situ, was 4.1%. Melanoma was the only discordant tumour that was associated with invasive and in situ skin SCC. These results provide evidence that there is an underlying hereditary susceptibility for at least a part of the familial clustering for skin SCC. (C) 2003 Cancer Research UK.
引用
收藏
页码:1375 / 1380
页数:6
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