Inhibition of human cytomegalovirus protease No with monocyclic β-lactams

被引：54

作者：

Déziel, R ^{[1
]}

Malenfant, E ^{[1
]}

机构：

[1] Boehringer Ingelheim Canada Ltd, Biomega Res Div, Laval, PQ H7S 2G5, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(98)00240-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Monocyclic beta-lactams have been identified as potent and selective inhibitors of the human cytomegalovirus protease (HCMV) N-o. Two series of these inhibitors are described, a peptidyl series of compounds and non-peptidic molecules featuring lower molecular weights. The SAR work that lead to the discovery of these inhibitors, together with their synthesis is also disclosed. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：1437 / +

页数：9

共 14 条

[1] Inhibition of human cytomegalovirus protease by benzoxazinones and evidence of antiviral activity in cell culture
Abood, NA
Schretzman, LA
Flynn, DL
Houseman, KA
Wittwer, AJ
Dilworth, VM
Hippenmeyer, PJ
Holwerda, BC
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (16) : 2105 - 2108
[2] Structure of the human cytomegalovirus protease catalytic domain reveals a novel serine protease fold and catalytic triad
Chen, P
Tsuge, H
Almassy, RJ
Gribskov, CL
Katoh, S
Vanderpool, DL
Margosiak, SA
Pinko, C
Matthews, DA
Kan, CC
[J]. CELL, 1996, 86 (05) : 835 - 843
[3] ORALLY-ACTIVE BETA-LACTAM INHIBITORS OF HUMAN-LEUKOCYTE ELASTASE .3. STEREOSPECIFIC SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS FOR 3,3-DIALKYLAZETIDIN-2-ONES
FINKE, PE
SHAH, SK
FLETCHER, DS
ASHE, BM
BRAUSE, KA
CHANDLER, GO
DELLEA, PS
HAND, KM
MAYCOCK, AL
OSINGA, DG
UNDERWOOD, DJ
WESTON, H
DAVIES, P
DOHERTY, JB
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (13) : 2449 - 2462
[4] Flynn D L, 1997, Drug Des Discov, V15, P3
[5] Gibson Wade, 1995, Perspectives in Drug Discovery and Design, V2, P413, DOI 10.1007/BF02172034
[6] Herpesvirus proteases: Targets for novel antiviral drugs
Holwerda, BC
[J]. ANTIVIRAL RESEARCH, 1997, 35 (01) : 1 - 21
[7] Potent selective thienoxazinone inhibitors of herpes proteases
Jarvest, RL
Connor, SC
Gorniak, JG
Jennings, LJ
Serafinowska, HT
West, A
[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (13) : 1733 - 1738
[8] LIU F, 1996, J VIROL, V65, P5149
[9] Peptidomimetic inhibitors of the human cytomegalovirus protease
Ogilvie, W
Bailey, M
Poupart, MA
Abraham, A
Bhavsar, A
Bonneau, P
Bordeleau, J
Bousquet, Y
Chabot, C
Duceppe, JS
Fazal, G
Goulet, S
GrandMaitre, C
Guse, I
Halmos, T
Lavallee, P
Leach, M
Malenfant, E
OMeara, J
Plante, R
Plouffe, C
Poirier, M
Soucy, F
Yoakim, C
Deziel, R
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (25) : 4113 - 4135
[10] Unique fold and active site in cytomegalovirus protease
Qiu, XY
Culp, JS
DiLella, AG
Hellmig, B
Hoog, SS
Janson, CA
Smith, WW
AbdelMeguid, SS
[J]. NATURE, 1996, 383 (6597) : 275 - 279

← 1 2 →