Liver transplantation for hepatocellular carcinoma in the world: the Taiwan experience

被引：10

作者：

Chen, Chao-Long ^{[1
,2
]}

Concejero, Allan M. ^{[1
,2
]}

机构：

[1] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Kaohsiung Med Ctr,Liver Transplant Program, Kaohsiung, Taiwan

[2] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Kaohsiung Med Ctr,Dept Surg, Kaohsiung, Taiwan

来源：

JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES | 2010年 / 17卷 / 05期

关键词：

Liver transplantation; Living-donor liver transplantation; Hepatocellular carcinoma; Taiwan; CHRONIC HEPATITIS-B; LIVING-DONOR; LOCOREGIONAL THERAPY; PROGNOSTIC VALUE; STAGING SYSTEMS; SURVIVAL; CANCER; INFECTION; COST; RISK;

D O I：

10.1007/s00534-009-0166-7

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Liver transplantation (LT) has been regarded as "potentially curative'' in a cirrhotic patient with hepatocellular carcinoma (HCC) because it removes the cancer and eradicates the cirrhosis. In Taiwan, HCC ranks first among the leading causes of cancer mortality in males and 4th in females. The most common causes are chronic hepatitis B virus-related cirrhosis, hepatitis C virus-related cirrhosis, and combined hepatitis B and C virus-related cirrhosis. The aggregate lifetime cost of hepatitis and HCC constitutes a significant burden on the Taiwanese health-care system. The reported overall (living-donor LT and deceased donor LT) 1- and 3-year survival rates for HCC after LT in Taiwan ranged from 86 to 98% and 61 to 96%, respectively. Microscopic vascular invasion did not influence the outcome of patients, but high alpha-fetoprotein levels >200 ng/ml may be a risk factor for HCC recurrence after transplant.

引用

页码：555 / 558

页数：4

共 31 条

[1] Long-term results of hepatic resection for hepatocellular carcinoma originating from the noncirrhotic liver [J].

Chang, CH ;

Chau, GY ;

Lui, WY ;

Tsay, SH ;

King, KL ;

Wu, CW .

ARCHIVES OF SURGERY, 2004, 139 (03) :320-325

[2] Metabolic factors and risk of hepatocellular carcinoma by chronic hepatitis B/C infection: A follow-up study in Taiwan [J].

Chen, Chi-Ling ;

Yang, Hwai-I ;

Yang, Wei-Shiung ;

Liu, Chun-Jen ;

Chen, Pei-Jer ;

You, San-Lin ;

Wang, Li-Yu ;

Sun, Chien-An ;

Lu, Sheng-Nan ;

Chen, Ding-Shin ;

Chen, Chien-Jen .

GASTROENTEROLOGY, 2008, 135 (01) :111-121

[3] Applicability of staging systems for patients with hepatocellular carcinoma is dependent on treatment method - Analysis of 2010 Taiwanese patients [J].

Chen, Chien-Hung ;

Hu, Fu-Chang ;

Huang, Guan-Tarn ;

Lee, Po-Huang ;

Tsang, Yuk-Ming ;

Cheng, Ann-Lii ;

Chen, Ding-Shinn ;

Wang, Jung-Der ;

Sheu, Jin-Chuan .

EUROPEAN JOURNAL OF CANCER, 2009, 45 (09) :1630-1639

[4] Hepatocellular carcinoma in Taiwan [J].

Chen, Ding-Shinn .

HEPATOLOGY RESEARCH, 2007, 37 :S101-S105

[5]

Chen SY, 2008, REV ESP ENFERM DIG, V100, P434, DOI 10.4321/s1130-01082008000700011

[6] Comparison of clinical staging systems in predicting survival of hepatocellular carcinoma patients receiving major or minor hepatectomy [J].

Chen, T. W. ;

Chu, C. M. ;

Yu, J. C. ;

Chen, C. J. ;

Chan, D. C. ;

Liu, Y. C. ;

Hsieh, C. B. .

EJSO, 2007, 33 (04) :480-487

[7]

Cheng Hau-Tsai, 2007, J Chin Med Assoc, V70, P310, DOI 10.1016/S1726-4901(08)70011-X

[8]

Cheng SJ, 2001, TRANSPLANTATION, V72, P861

[9]

Cheng YF, 2005, WORLD J GASTROENTERO, V11, P1433

[10] Living donor liver transplantation for hepatocellular carcinoma: a single-center experience in Taiwan [J].

Concejero, Allan ;

Chen, Chao-Long ;

Wang, Chih-Chi ;

Wang, Shih-Ho ;

Lin, Chih-Che ;

Liu, Yueh-Wei ;

Yang, Chin-Hsiang ;

Yong, Chee-Chien ;

Lin, Tsan-Shiun ;

Jawan, Bruno ;

Huang, Tung-Liang ;

Cheng, Yu-Fan ;

Eng, Hock-Liew .

TRANSPLANTATION, 2008, 85 (03) :398-406

← 1 2 3 4 →