Vitamin D in Atopic Dermatitis, Asthma and Allergic Diseases

被引：121

作者：

Searing, Daniel A. ^{[1
]}

Leung, Donald Y. M. ^{[1
,2
]}

机构：

[1] Natl Jewish Hlth, Div Pediat Allergy & Immunol, Dept Pediat, Denver, CO 80206 USA

[2] Univ Colorado, Dept Pediat, Childrens Hosp, Aurora, CO 80045 USA

来源：

IMMUNOLOGY AND ALLERGY CLINICS OF NORTH AMERICA | 2010年 / 30卷 / 03期

关键词：

Vitamin D; Atopic dermatitis; Asthma; Allergy; REGULATORY T-CELLS; D DEFICIENCY; D-RECEPTOR; 1-ALPHA; 25-DIHYDROXYVITAMIN D-3; ANTIMICROBIAL PEPTIDES; D SUPPLEMENTATION; CHILDHOOD ASTHMA; DENDRITIC CELLS; CHILDREN; SKIN;

D O I：

10.1016/j.iac.2010.05.005

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

This review examines the scientific evidence behind the hypothesis that vitamin D plays a role in the pathogenesis of allergic diseases, along with a focus on emerging data regarding vitamin D and atopic dermatitis. Elucidated molecular interactions of vitamin D with components of the immune system and clinical data regarding vitamin D deficiency and atopic diseases are discussed. The rationale behind the sunshine hypothesis, laboratory evidence supporting links between vitamin D deficiency and allergic diseases, the clinical evidence for and against vitamin D playing a role in allergic diseases, and the emerging evidence regarding the potential use of vitamin D to augment the innate immune response in atopic dermatitis are reviewed.

引用

页码：397 / +

页数：15

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