Two New Curine-Type Bisbenzylisoquinoline Alkaloids from the Roots of Cyclea wattii with Cytotoxic Activities

被引：11

作者：

Wang, Jian-Zhong ^{[1
]}

Liu, Xiao-Yu ^{[1
]}

Wang, Feng-Peng ^{[1
]}

机构：

[1] Sichuan Univ, Dept Chem Med Nat Prod, W China Coll Pharm, Chengdu 610041, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 07期

关键词：

Cyclea wattii; bisbenzylisoquinoline alkaloid; wattisine A; wattisine B; cytotoxic activity; SPECTROSCOPY;

D O I：

10.1248/cpb.58.986

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Two new curine-type bisbenzylisoquinoline alkaloids, wattisines A (1) and B (2) along with three known alkaloids were isolated from the roots of Cyclea wattii. Their structures were established by interpretation of NMR and high-resolution electrospray ionization (ESI)-MS data. Absolute configuration of wattisines A and B were determined by single-crystal X-ray diffraction and circular dichroism (CD) spectra, respectively. In vitro, wattisine A (1) showed significant cytotoxic activities with IC50 value of 1.74 mu M against HCT-8, and 7.29 mu M against Bel-7402.

引用

页码：986 / 988

页数：3

共 9 条

[1] Antiplasmodial and cytotoxic activity of natural bisbenzylisoquinoline alkaloids [J].

Angerhofer, CK ;

Guinaudeau, H ;

Wongpanich, V ;

Pezzuto, JM ;

Cordell, GA .

JOURNAL OF NATURAL PRODUCTS, 1999, 62 (01) :59-66

[2]

GUHA K P, 1979, Journal of Natural Products (Lloydia), V42, P1, DOI 10.1021/np50001a001

[3] PROTON AND C-13 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY AND CONFORMATIONAL ASPECTS OF THE CURINE CLASS OF BIS(BENZYLISOQUINOLINE) ALKALOIDS [J].

KOIKE, L ;

MARSAIOLI, AJ ;

REIS, FAM .

JOURNAL OF ORGANIC CHEMISTRY, 1981, 46 (11) :2385-2389

[4]

KOIKE L, 1979, TETRAHEDRON LETT, P3765

[5]

Ndaya T J, 2003, PHYTOCHEM ANALYSIS, V14, P13

[6]

PAUL L, 1983, J NAT PRODUCTS, V46, P1

[7]

Paul L., 1997, J. Nat. Prod, V60, P934

[8]

Tanahashi T, 2000, CHEM PHARM BULL, V48, P370

[9]

TOMITA M, 1966, TETRAHEDRON LETT, P857

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