Peniginsengins B-E, New Farnesylcyclohexenones from the Deep Sea-Derived Fungus Penicillium sp YPGA11

被引：17

作者：

Cheng, Zhongbin ^{[1
,4
]}

Xu, Wei ^{[2
]}

Liu, Lijun ^{[1
]}

Li, Shumin ^{[1
]}

Yuan, Wangjun ^{[1
,3
]}

Luo, Zhuhua ^{[3
]}

Zhang, Jingjie ^{[1
]}

Cheng, Yongjun ^{[1
]}

Li, Qin ^{[1
,3
]}

机构：

[1] Henan Univ, Coll Pharm, Kaifeng 475004, Peoples R China

[2] State Ocean Adm, Inst Oceanog 3, Key Lab Marine Biogenet Resources, Xiamen 361005, Peoples R China

[3] Eucommia Ulmoides Cultivat & Utilizat Henan Engn, Kaifeng 475004, Peoples R China

[4] Henan Univ, Coll Chem & Chem Engn, Kaifeng 475004, Peoples R China

来源：

MARINE DRUGS | 2018年 / 16卷 / 10期

基金：

中国博士后科学基金; 国家重点研发计划;

关键词：

Penicillium sp; deep sea-derived fungus; farnesylcyclohexenones; antibacterial; AMBUIC ACID-DERIVATIVES; MARINE NATURAL-PRODUCTS; ASPERGILLUS-NIGER; PESTALOTIOPSIS SP; YANUTHONES; METABOLITES; ALKALOIDS;

D O I：

10.3390/md16100358

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Chemical examination of the EtOAc extract of the deep sea-derived fungus Penicillium sp. YPGA11 resulted in the isolation of four new farnesylcyclohexenones, peniginsengins B-E (1-4), and a known analog peniginsengin A (5). The structures of compounds 1-4 were determined on the basis of comprehensive analyses of the nuclear magnetic resonance (NMR) and mass spectroscopy (MS) data, and the absolute configurations of 1, 2, and 4 were determined by comparisons of experimental electronic circular dichroism (ECD) with calculated ECD spectra. Compounds 1-5, characterized by a highly oxygenated 1-methylcyclohexene unit and a (4E,8E)-4,8-dimethyldeca-4,8-dienoic acid side chain, are rarely found in nature. Compounds 2-4 exhibited antibacterial activity against Staphylococcus aureus.

引用

页数：10

共 27 条

[1] Marine natural products
Blunt, John W.
Carroll, Anthony R.
Copp, Brent R.
Davis, Rohan A.
Keyzers, Robert A.
Prinsep, Michele R.
[J]. NATURAL PRODUCT REPORTS, 2018, 35 (01) : 8 - 53
[2] Yanuthones:: Novel metabolites from a marine isolate of Aspergillus niger
Bugni, TS
Abbanat, D
Bernan, VS
Maiese, WM
Greenstein, M
Van Wagoner, RM
Ireland, CM
[J]. JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (21) : 7195 - 7200
[3] Versicotides D-F, new cyclopeptides with lipid-lowering activities
Chen, Ran
Cheng, Zhongbin
Huang, Jian
Liu, Dong
Wu, Chongming
Guo, Peng
Lin, Wenhan
[J]. RSC ADVANCES, 2017, 7 (78): : 49235 - 49243
[4] Bioactive polyhydroxylated sterols from the marine sponge Haliclona crassiloba
Cheng, Zhong-Bin
Xiao, Han
Fan, Cheng-Qi
Lu, Ya-Nan
Zhang, Ge
Yin, Sheng
[J]. STEROIDS, 2013, 78 (14) : 1353 - 1358
[5] Versiquinazolines A-K, Fumiquinazoline-Type Alkaloids from the Gorgonian-Derived Fungus Aspergillus versicolor LZD-14-1
Cheng, Zhongbin
Lou, Lanlan
Liu, Dong
Li, Xiaodan
Proksch, Peter
Yin, Sheng
Lin, Wenhan
[J]. JOURNAL OF NATURAL PRODUCTS, 2016, 79 (11): : 2941 - 2952
[6] Eremophilane-Type Sesquiterpenoids from an Acremonium sp Fungus Isolated from Deep-Sea Sediments
Cheng, Zhongbin
Zhao, Jingjun
Liu, Dong
Proksch, Peter
Zhao, Zhimin
Lin, Wenhan
[J]. JOURNAL OF NATURAL PRODUCTS, 2016, 79 (04): : 1035 - 1047
[7] Ambuic Acid and Torreyanic Acid Derivatives from the Endolichenic Fungus Pestalotiopsis sp.
Ding, Gang
Li, Yan
Fu, Shaobin
Liu, Shuchun
Wei, Jiangchun
Che, Yongsheng
[J]. JOURNAL OF NATURAL PRODUCTS, 2009, 72 (01): : 182 - 186
[8] Secondary Metabolites from a Marine-Derived Endophytic Fungus Penicillium chrysogenum QEN-24S
Gao, Shu-Shan
Li, Xiao-Ming
Du, Feng-Yu
Li, Chun-Shun
Proksch, Peter
Wang, Bin-Gui
[J]. MARINE DRUGS, 2011, 9 (01): : 59 - 70
[9] Penicyclones A-E, Antibacterial Polyketides from the Deep-Sea-Derived Fungus Penicillium sp F23-2
Guo, Wenqiang
Zhang, Zhenzhen
Zhu, Tianjiao
Gu, Qianqun
Li, Dehai
[J]. JOURNAL OF NATURAL PRODUCTS, 2015, 78 (11): : 2699 - 2703
[10] Three New Indole Diterpenoids from the Sea-Anemone-Derived Fungus Penicillium sp AS-79
Hu, Xue-Yi
Meng, Ling-Hong
Li, Xin
Yang, Sui-Qun
Li, Xiao-Ming
Wang, Bin-Gui
[J]. MARINE DRUGS, 2017, 15 (05):

← 1 2 3 →