Peniginsengins B-E, New Farnesylcyclohexenones from the Deep Sea-Derived Fungus Penicillium sp YPGA11

被引：17
作者：
Cheng, Zhongbin [1 ,4 ]
Xu, Wei [2 ]
Liu, Lijun [1 ]
Li, Shumin [1 ]
Yuan, Wangjun [1 ,3 ]
Luo, Zhuhua [3 ]
Zhang, Jingjie [1 ]
Cheng, Yongjun [1 ]
Li, Qin [1 ,3 ]
机构：
[1] Henan Univ, Coll Pharm, Kaifeng 475004, Peoples R China
[2] State Ocean Adm, Inst Oceanog 3, Key Lab Marine Biogenet Resources, Xiamen 361005, Peoples R China
[3] Eucommia Ulmoides Cultivat & Utilizat Henan Engn, Kaifeng 475004, Peoples R China
[4] Henan Univ, Coll Chem & Chem Engn, Kaifeng 475004, Peoples R China
来源：
MARINE DRUGS | 2018年 / 16卷 / 10期
基金：
国家重点研发计划; 中国博士后科学基金;
关键词：
Penicillium sp; deep sea-derived fungus; farnesylcyclohexenones; antibacterial; AMBUIC ACID-DERIVATIVES; MARINE NATURAL-PRODUCTS; ASPERGILLUS-NIGER; PESTALOTIOPSIS SP; YANUTHONES; METABOLITES; ALKALOIDS;
D O I：
10.3390/md16100358
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Chemical examination of the EtOAc extract of the deep sea-derived fungus Penicillium sp. YPGA11 resulted in the isolation of four new farnesylcyclohexenones, peniginsengins B-E (1-4), and a known analog peniginsengin A (5). The structures of compounds 1-4 were determined on the basis of comprehensive analyses of the nuclear magnetic resonance (NMR) and mass spectroscopy (MS) data, and the absolute configurations of 1, 2, and 4 were determined by comparisons of experimental electronic circular dichroism (ECD) with calculated ECD spectra. Compounds 1-5, characterized by a highly oxygenated 1-methylcyclohexene unit and a (4E,8E)-4,8-dimethyldeca-4,8-dienoic acid side chain, are rarely found in nature. Compounds 2-4 exhibited antibacterial activity against Staphylococcus aureus.
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页数：10
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