Implication of JAK1, JAK2, and JAK3 in the Realization of Proliferation and Differentiation Potential of Mesenchymal Progenitor Cells In Vitro

被引：3
|
作者：
Zyuz'kov, G. N. [1 ,2 ]
Zhdanov, V. V. [1 ]
Udut, E. V. [1 ]
Miroshnichenko, L. A. [1 ]
Simanina, E. V. [1 ]
Polyakova, T. Yu. [1 ]
Chaikovskii, A. V. [1 ]
Stavrova, L. A. [1 ]
Udut, V. V. [2 ]
Agafonov, V. I. [1 ]
Burmina, Ya. V. [1 ]
Danilets, M. G. [1 ]
Minakova, M. Yu. [1 ]
Dygai, A. M. [1 ]
机构：
[1] ED Goldberg Res Inst Pharmacol & Regenerat Med, Tomsk, Russia
[2] Natl Res Tomsk State Univ, Tomsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2016年 / 161卷 / 02期
关键词：
signal pathways; JAK kinases; progenitor cells; regenerative medicine; pharmacological control; COLONY-STIMULATING FACTOR; FUNCTIONAL STIMULATION; ALKALOID SONGORINE; PRECURSOR CELLS; BRAIN ISCHEMIA; HYALURONIDASE; MECHANISMS; STATS; Z77;
D O I：
10.1007/s10517-016-3381-7
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Involvement of individual JAK kinases in the realization of growth potential of mesenchymal progenitor cells was examined in vitro. Important role of JAK2 and JAK3 in determining the initial level of mitotic activity of progenitor cells was established. The yield of fibroblast CFUF was suppressed under the effect of specific inhibitors of JAK kinases. Blockade of JAK3 increased the rate of progenitor element differentiation. JAK1 had no effect on proliferation and differentiation status of progenitor cells.
引用
收藏
页码：224 / 227
页数：4
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