Autoimmune thrombocytopenia in chronic myeloid leukemia treated with interferon-alpha: Differential diagnosis and possible pathogenesis

被引：6

作者：

Herishanu, Y ^{[1
]}

Trestman, S ^{[1
]}

Kirgner, I ^{[1
]}

Rachmani, R ^{[1
]}

Naparstek, E ^{[1
]}

机构：

[1] Tel Aviv Sourasky Med Ctr, Dept Hematol, Tel Aviv, Israel

来源：

LEUKEMIA & LYMPHOMA | 2003年 / 44卷 / 12期

关键词：

autoimmune thrombocytopenia; interferon-alpha; chronic myeloid leukemia;

D O I：

10.1080/1042819031000123447

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Interferon-alpha (INF-alpha) is an effective anti-neoplastic and anti-viral drug. Treatment with INF-alpha is frequently complicated by adverse effects, which may rarely be immune mediated. We report 2 patients with Ph+ chronic myeloid leukemia (CML) who developed autoimmune thrombocytopenia while receiving months of treatment with INF-alpha. This complication responded well to discontinuation of interferon and administration of steroids treatment. Here, we also summarize the literature on INF-alpha induced autoimmune thrombocytopenia, and discuss differential diagnosis and possible mechanisms involved in the development of thrombocytopenia during therapy with INF-alpha.

引用

页码：2103 / 2108

页数：6

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