Anticancer function of polyinosinic-polycytidylic acid

被引:109
作者
Cheng, Yu-Sheng [1 ]
Xu, Feng [1 ]
机构
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Resp Med, Hangzhou 310003, Zhejiang, Peoples R China
关键词
polyi-c; signaling pathway; tumor immunotherapy; TLR3; RIG-I; MDA-5; apoptosis; TOLL-LIKE RECEPTOR-3; DOUBLE-STRANDED-RNA; NF-KAPPA-B; RIG-I; ACID/CATIONIC LIPOSOME; IMMUNE-RESPONSE; CELLS; CANCER; ACTIVATION; APOPTOSIS;
D O I
10.4161/cbt.10.12.13450
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Polyinosinic-polycytidylic acid (polyi:c) is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor (TLR) 3 and retinoic acid inducible gene I (RIG-I)-like receptors (RLRs), including RIG-I and melanoma differentiation-associated gene 5 (MDA5). The effect of polyi:c on tumor immunotherapy has been well explored for several decades. The accumulated evidence suggests that polyi:c could be used as a vaccine adjuvant to enhance innate and adaptive immune responses, and to alter the tumor microenvironment. Recent studies have also shown that activation of TLR3 and RLR signaling by polyi:c can directly trigger apoptosis in some cancer cells. This review focuses on polyi:c-induced signaling pathways and the applications of polyi:c in cancer treatment.
引用
收藏
页码:1219 / 1223
页数:5
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