Role of gut microbiota in type 2 diabetes pathophysiology

被引:1103
作者
Gurung, Manoj [1 ]
Li, Zhipeng [1 ]
You, Hannah [1 ]
Rodrigues, Richard [2 ]
Jump, Donald B. [3 ]
Morgun, Andrey [2 ]
Shulzhenko, Natalia [1 ]
机构
[1] Oregon State Univ, Coll Vet Med, 700 SW 30th St, Corvallis, OR 97331 USA
[2] Oregon State Univ, Coll Pharm, 160 SW 26th St, Corvallis, OR 97331 USA
[3] Oregon State Univ, Coll Publ Hlth, 160 SW 26th St, Corvallis, OR 97331 USA
来源
EBIOMEDICINE | 2020年 / 51卷
关键词
Type; 2; diabetes; Microbiota; 16S rRNA; Metagenomics; Insulin resistance; HIGH-FAT DIET; LACTOBACILLUS-CASEI CCFM419; INSULIN-RESISTANCE; AKKERMANSIA-MUCINIPHILA; INTESTINAL MICROBIOTA; BARIATRIC SURGERY; METABOLIC PROFILES; GLUCOSE-TOLERANCE; OXIDATIVE STRESS; GLYCEMIC CONTROL;
D O I
10.1016/j.ebiom.2019.11.051
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A substantial body of literature has provided evidence for the role of gut microbiota in metabolic diseases including type 2 diabetes. However, reports vary regarding the association of particular taxonomic groups with disease. In this systematic review, we focused on the potential role of different bacterial taxa affecting diabetes. We have summarized evidence from 42 human studies reporting microbial associations with disease, and have identified supporting preclinical studies or clinical trials using treatments with probiotics. Among the commonly reported findings, the genera of Bifidobacterium, Bacteroides, Faecalibacterium, Akkermansia and Roseburia were negatively associated with T2D, while the genera of Ruminococcus, Fusobacterium, and Blautia were positively associated with T2D. We also discussed potential molecular mechanisms of microbiota effects in the onset and progression of T2D. (C) 2019 The Authors. Published by Elsevier B.V.
引用
收藏
页数:9
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