Well-being at work is a productivity factor and source of an organization (Boyd, 1997). Organizational structures and employee places evolve, in particular with creative organization apparition (Woodman, Sawyer, and Griffin, 1993). Hence, aim of this exploratory study is to study the impact of management mode of intrapreneurial forms of new organizations, defined by Slevin and Covin (2010), on well-being at work. Slevin & Covin (2010) have defined four intrapreneurial management modes, with two variables : management style (Slevin and Covin, 1990) and organizational structure : mechanistic and organic structure (Slevin and Covin, 1990). We have asked sample of thirteen individual, who were allocated in two groups : innovation managers and employees. In order to measure well-being at work in two different populations, we have distinguished extrinsic factors of well-being at work (Weiss and al., 1967; Donia, Gagne, Houlfort, and Koestner, 2007; Bietry and Creusier, 2013) and intrinsic factors of well-being at work (Weiss and al., 1967; Donia, Gagne, Houlfort, and Koestner, 2007; Bietry and Creusier, 2013). In order to collect data and to attend our purpose, we have used semi-structured interview methodology (Imbert, 2010). According to the different types of entrepreneurial dynamic models, the results show that individual use different factors to explain well-being or ill-being at work.