Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses

被引：234

作者：

Yen, Chun-Wan ^{[1
,2
]}

de Puig, Helena ^{[3
]}

Tam, Justina O. ^{[1
,2
]}

Gomez-Marquez, Jose ^{[4
,5
]}

Bosch, Irene ^{[1
,2
]}

Hamad-Schifferli, Kimberly ^{[3
,6
]}

Gehrke, Lee ^{[1
,7
]}

机构：

[1] MIT, Inst Med Engn & Sci, Cambridge, MA 02139 USA

[2] US FDA, Winchester Engn Analyt Ctr, Winchester, MA 01890 USA

[3] MIT, Dept Mech Engn, Cambridge, MA 02139 USA

[4] MIT, Little Devices Lab, Cambridge, MA 02139 USA

[5] MIT SUTD Int Design Ctr, Cambridge, MA USA

[6] MIT, Lincoln Lab, Lexington, MA 02420 USA

[7] Harvard Univ, Sch Med, Dept Microbiol & Immunobiol, Boston, MA 02115 USA

来源：

LAB ON A CHIP | 2015年 / 15卷 / 07期

关键词：

PROTEIN NS1; GOLD; ANTIGEN;

D O I：

10.1039/c5lc00055f

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Rapid point-of-care (POC) diagnostic devices are needed for field-forward screening of severe acute systemic febrile illnesses. Multiplexed rapid lateral flow diagnostics have the potential to distinguish among multiple pathogens, thereby facilitating diagnosis and improving patient care. Here, we present a platform for multiplexed pathogen detection using multi-colored silver nanoplates. This design requires no external excitation source and permits multiplexed analysis in a single channel, facilitating integration and manufacturing.

引用

页码：1638 / 1641

页数：4

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