Restoration of cellular energetic balance with L-carnitine in the neuro-bioenergetic approach for cancer prevention and treatment

被引：7
作者：
Hoang, Ba X.
Shaw, D. Graeme
Pham, Phuong
Levine, Stephen
机构：
[1] Allergy Res Grp, San Jose, CA 95117 USA
[2] Adv Integrat Med, Los Altos, CA 94022 USA
[3] Univ So Calif, Dept Mol Biol, Los Angeles, CA 90089 USA
[4] Allergy Res Grp, Alameda, CA 94502 USA
来源：
MEDICAL HYPOTHESES | 2007年 / 69卷 / 02期
关键词：
D O I：
10.1016/j.mehy.2006.11.049
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Mitochondrial research has contributed to two paradigm shifts in oncology - Warburg's glycolytic metabolism and the relationship between mitochondrial function and mutagenesis. Mitochondrial dysfunction is a common phenotype in aging and cancer. Decline in mitochondrial function is due to the accumulation of mutations in mitochondrial DNA. We have hypothesized a neuro-bioenergetic concept in cancer prevention and treatment to constructively restore three physiological imbalances of cancer patients: membrane hyper-excitabitity, energy depletion and the build up of extra-cellular adenosine molecules. We have proposed the use of membrane-calming substances to reduce energy consumption and to restore the normal cellular energy metabolism. Based on our theory, L-carnitine's dual effect of enhanced energy production and excitatory neurotransmitter modulation should make it an ideal nutrient for cancer prevention and treatment. L-carnitine, its derivatives and other mitochondrial protectors/ enhancers improve metabolic function, energy and detoxification. In combination with other membrane calming agents, L-carnitine could help reverse the membrane hyper-excitability to overcome a neuro-bioenergetic imbalance and can be used as a relevant and effective approach for cancer
引用
收藏
页码：262 / 272
页数：11
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