Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells

被引：346

作者：

Chen, Hsiuchen ^{[1
]}

Chan, David C. ^{[1
]}

机构：

[1] CALTECH, Div Biol & Biol Engn, 1200 East Calif Blvd,MC 114-96, Pasadena, CA 91125 USA

来源：

CELL METABOLISM | 2017年 / 26卷 / 01期

关键词：

TUMOR-INITIATING CELLS; EMBRYONIC-DEVELOPMENT; PEROXISOMAL FISSION; SYNAPSE FORMATION; DRP1; RECRUITMENT; MAMMALIAN-CELLS; OPTIC ATROPHY; PROTEIN DRP1; SELF-RENEWAL; MITOFUSIN;

D O I：

10.1016/j.cmet.2017.05.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Cancer and stem cells appear to share a common metabolic profile that is characterized by high utilization of glucose through aerobic glycolysis. In the presence of sufficient nutrients, this metabolic strategy provides sufficient cellular ATP while additionally providing important metabolites necessary for the biosynthetic demands of continuous cell proliferation. Recent studies indicate that this metabolic profile is dependent on genes that regulate the fusion and fission of mitochondria. High levels of mitochondrial fission activity are associated with high proliferation and invasiveness in some cancer cells and with self-renewal and resistance to differentiation in some stem cells. These observations reveal new ways in which mitochondria regulate cell physiology, through their effects on metabolism and cell signaling.

引用

页码：39 / 48

页数：10

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