Pyroptosis: A promising therapeutic target for noninfectious diseases

被引：37

作者：

Li, Tong ^{[1
,2
,3
]}

Zheng, Guangjuan ^{[1
,2
,4
]}

Li, Ben ^{[3
]}

Tang, Lipeng ^{[1
,2
]}

机构：

[1] Guangzhou Univ Chinese Med, Affiliated Hosp 2, State Key Lab Dampness Syndrome Chinese Med, 111 Dade Rd, Guangzhou 510120, Peoples R China

[2] Guangzhou Univ Chinese Med, Clin Coll 2, Dept Pharmacol Tradit Chinese Med, 111 Dade Rd, Guangzhou 510120, Peoples R China

[3] Guangzhou Univ Chinese Med, Clin Coll 2, Dept Pharm, 111 Dade Rd, Guangzhou 510120, Peoples R China

[4] Guangzhou Univ Chinese Med, Clin Coll 2, Dept Pathol, Guangzhou, Peoples R China

来源：

CELL PROLIFERATION | 2021年 / 54卷 / 11期

关键词：

DRUGS INDUCE PYROPTOSIS; SMOOTH-MUSCLE-CELLS; NLRP3; INFLAMMASOME; GASDERMIN D; PARKINSONS-DISEASE; GASTRIC-CANCER; DEATH; CLEAVAGE; INJURY; MICE;

D O I：

10.1111/cpr.13137

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pyroptosis, which is characterized by gasdermin family protein-mediated pore formation, cellular lysis and the release of pro-inflammatory cytokines, is a form of programmed cell death associated with intracellular pathogens-induced infection. However, emerging evidence indicates that pyroptosis also contributes to sterile inflammation. In this review, we will first illustrate the biological process of pyroptosis. Then, we will focus on the pathogenic effects of pyroptosis on multiple noninfectious disorders. At last, we will characterize several specific pyroptotic inhibitors targeting the pyroptotic signalling pathway. These data demonstrate that pyroptosis plays a prominent role in sterile diseases, thereby providing a promising approach to the treatment of noninfective inflammatory disorders.

引用

页数：17

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