Molecular genetics and clinical applications for RH

被引：149

作者：

Flegel, Willy A. ^{[1
]}

机构：

[1] NIH, Dept Transfus Med, Ctr Clin, Bethesda, MD 20892 USA

来源：

TRANSFUSION AND APHERESIS SCIENCE | 2011年 / 44卷 / 01期

关键词：

Rhesus; Blood group; Molecular genetics; Molecular diagnostic; Transfusion; WEAK-D-TYPES; POLYMERASE-CHAIN-REACTION; AMINO-ACID SUBSTITUTIONS; ANTI-D ALLOIMMUNIZATION; TIME QUANTITATIVE PCR; BLOOD-GROUP ANTIGENS; MATERNAL PLASMA; FETAL DNA; HEMOLYTIC-DISEASE; RED-CELLS;

D O I：

10.1016/j.transci.2010.12.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rhesus is the clinically most important protein-based blood group system. It represents the largest number of antigens and the most complex genetics of the 30 known blood group systems. The RHO and RHCE genes are strongly homologous. Some genetic complexity is explained by their close chromosomal proximity and unusual orientation, with their tail ends facing each other. The antigens are expressed by the RhD and the RhCE proteins. Rhesus exemplifies the correlation of genotype and phenotype, facilitating the understanding of general genetic mechanisms. For clinical purposes, genetic diagnostics of Rhesus antigens will improve the cost-effective development of transfusion medicine. Published by Elsevier Ltd.

引用

页码：81 / 91

页数：11

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