Voriconazole: A second-generation triazole

被引：85
作者：
Chandrasekar, PH [1 ]
Manavathu, E [1 ]
机构：
[1] Wayne State Univ, Sch Med, Detroit Med Ctr, Dept Med,Div Infect Dis, Detroit, MI 48201 USA
来源：
DRUGS OF TODAY | 2001年 / 37卷 / 02期
关键词：
D O I：
10.1358/dot.2001.37.2.614849
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Voriconazole, a derivative of fluconazole, is an antifungal triazole with expanded spectrum of activity against a variety of yeasts and filamentous fungi, It exhibits fungicidal activity against Aspergillus species. Preliminary data from animal models and clinical trials show promise in the treatment of candidiasis and aspergillosis. Of concern is the development of resistance to voriconazole and cross-resistance with other azoles. Voriconazole is a welcome addition to our limited armamentarium against potentially fatal fungal infections, (C) 2001 Prous Science. All rights reserved.
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页码：135 / 148
页数：14
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