Voriconazole: A second-generation triazole

被引：85
作者：
Chandrasekar, PH [1 ]
Manavathu, E [1 ]
机构：
[1] Wayne State Univ, Sch Med, Detroit Med Ctr, Dept Med,Div Infect Dis, Detroit, MI 48201 USA
来源：
DRUGS OF TODAY | 2001年 / 37卷 / 02期
关键词：
D O I：
10.1358/dot.2001.37.2.614849
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Voriconazole, a derivative of fluconazole, is an antifungal triazole with expanded spectrum of activity against a variety of yeasts and filamentous fungi, It exhibits fungicidal activity against Aspergillus species. Preliminary data from animal models and clinical trials show promise in the treatment of candidiasis and aspergillosis. Of concern is the development of resistance to voriconazole and cross-resistance with other azoles. Voriconazole is a welcome addition to our limited armamentarium against potentially fatal fungal infections, (C) 2001 Prous Science. All rights reserved.
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页码：135 / 148
页数：14
相关论文
共 77 条
[1]  
ABRAHAM OC, 1998, DIAGN MICROBIOL INFE, V33, P7
[2]   EVIDENCE FOR DUAL PHYSIOLOGICAL FORMS OF ERGOSTEROL IN SACCHAROMYCES CEREVISIAE [J].
ADAMS, BG ;
PARKS, LW .
JOURNAL OF CELLULAR PHYSIOLOGY, 1967, 70 (2P1) :161-&
[3]   In vitro activities of the new antifungal triazole SCH 56592 against common and emerging yeast pathogens [J].
Barchiesi, F ;
Arzeni, D ;
Fothergill, AW ;
Di Francesco, LF ;
Caselli, F ;
Rinaldi, MG ;
Scalise, G .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2000, 44 (01) :226-229
[4]   Voriconazole (UK-109,496) inhibits the growth and alters the morphology of fluconazole-susceptible and -resistant Candida species [J].
Belanger, P ;
Nast, CC ;
Fratti, R ;
Sanati, H ;
Ghannoum, M .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (08) :1840-1842
[5]   STEROL STRUCTURE AND MEMBRANE-FUNCTION [J].
BLOCH, KE .
CRC CRITICAL REVIEWS IN BIOCHEMISTRY, 1983, 14 (01) :47-92
[6]   MODELING CYTOCHROME-P450 14-ALPHA DEMETHYLASE (CANDIDA-ALBICANS) FROM P450CAM [J].
BOSCOTT, PE ;
GRANT, GH .
JOURNAL OF MOLECULAR GRAPHICS & MODELLING, 1994, 12 (03) :185-192
[7]   Efficacy of voriconazole against invasive pulmonary aspergillosis in a guinea-pig model [J].
Chandrasekar, PH ;
Cutright, J ;
Manavathu, E .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2000, 45 (05) :673-676
[8]  
Chiou C C, 2000, Oncologist, V5, P120, DOI 10.1634/theoncologist.5-2-120
[9]   Microgranulomatous aspergillosis in a patient with chronic granulomatous disease:: Cure with voriconazole [J].
de Sévaux, RGL ;
Kullberg, BJ ;
Verweij, PE ;
van de Nes, JAP ;
Meis, JFGM ;
van der Meer, JWM .
CLINICAL INFECTIOUS DISEASES, 1998, 26 (04) :996-997
[10]  
DENNING D, 1995, 35 INT C ANT AG CHEM
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