Old and new antiepileptic drugs during pregnancy and lactation - report of a case

被引：8

作者：

Rauchenzauner, Markus ^{[1
,2
]}

Kiechl-Kohlendorfer, Ursula ^{[2
]}

Rostasy, Kevin ^{[2
]}

Luef, Gerhard ^{[3
]}

机构：

[1] Schon Klin Vogtareuth, Neuropediat Dept, D-83569 Vogtareuth, Germany

[2] Med Univ Innsbruck, Dept Pediat 4, Innsbruck, Austria

[3] Med Univ Innsbruck, Dept Neurol, Innsbruck, Austria

来源：

EPILEPSY & BEHAVIOR | 2011年 / 20卷 / 04期

关键词：

Breastfeeding; Antiepileptic drugs; Women with epilepsy; Neonatal seizures; EPILEPSY; WOMEN; PHARMACOKINETICS; PERIOD;

D O I：

10.1016/j.yebeh.2011.01.028

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

We describe a case of a woman with epilepsy treated with primidone/phenobarbital (so-called "old" antiepileptic drug) and levetiracetam (so-called "new" antiepileptic drug) who was discouraged from breastfeeding, resulting in clinically significant withdrawal seizures in her newborn. As a consequence, even when two or more antiepileptic drugs are needed for the treatment of women with epilepsy, breastfeeding should be recommended, mothers should be informed about the possiblity of drug effects on the neonate, and infants of mothers treated with primidone/phenobarbital should be closely monitored for possible signs of sedation. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：719 / 720

页数：2

共 12 条

[1] Italian Consensus Conference on Epilepsy and Pregnancy, Labor and Puerperium [J].

Aguglia, Umberto ;

Barboni, Giancarlo ;

Battino, Dina ;

Cavazzuti, Giovan Battista ;

Citernesi, Angela ;

Corosu, Roberto ;

Guzzetta, Francesco Maria ;

Iannetti, Paola ;

Mamoli, Daniela ;

Patella, Alfredo ;

Pavone, Lorenzo ;

Perucca, Emilio ;

Primiero, Francesco ;

Pruna, Dario ;

Savasta, Salvatore ;

Specchio, Luigi Maria ;

Verrotti, Alberto .

EPILEPSIA, 2009, 50 :7-23

[2] Anticonvulsants and breast feeding: A critical review [J].

Bar-Oz B. ;

Nulman I. ;

Koren G. ;

Ito S. .

Pediatric Drugs, 2000, 2 (2) :113-126

[3] Managing Epilepsy in Women of Childbearing Age [J].

Crawford, Pamela M. .

DRUG SAFETY, 2009, 32 (04) :293-307

[4] Descriptive epidemiology of epilepsy: Contributions of population-based studies from Rochester, Minnesota [J].

Hauser, WA ;

Annegers, JF ;

Rocca, WA .

MAYO CLINIC PROCEEDINGS, 1996, 71 (06) :576-586

[5]

KNOTT C, 1987, LANCET, V2, P272

[6] PRIMIDONE AND PHENOBARBITAL DURING LACTATION PERIOD IN EPILEPTIC WOMEN - TOTAL AND FREE DRUG SERUM LEVELS IN THE NURSED INFANTS AND THEIR EFFECTS ON NEONATAL BEHAVIOR [J].

KUHNZ, W ;

KOCH, S ;

HELGE, H ;

NAU, H .

DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS, 1988, 11 (03) :147-154

[7] Effects of breastfeeding in children of women taking antiepileptic drugs [J].

Meador, K. J. ;

Baker, G. A. ;

Browning, N. ;

Clayton-Smith, J. ;

Combs-Cantrell, D. T. ;

Cohen, M. ;

Kalayjian, L. A. ;

Kanner, A. ;

Liporace, J. D. ;

Pennell, P. B. ;

Privitera, M. ;

Loring, D. W. .

NEUROLOGY, 2010, 75 (22) :1954-1960

[8] Antiepileptic drug pharmacokinetics during pregnancy and lactation [J].

Pennell, PB .

NEUROLOGY, 2003, 61 (06) :S35-S42

[9]

Report of the Quality Standards Subcommittee of the American Academy of Neurology, 1998, NEUROLOGY, V51, P944

[10] Gender aspects of pharmacokinetics of new and old AEDs - Pregnancy and breast-feeding [J].

Tomson, T .

THERAPEUTIC DRUG MONITORING, 2005, 27 (06) :718-721

← 1 2 →