The role of IL-22 in intestinal health and disease

被引：320

作者：

Keir, Mary E. ^{[1
]}

Yi, Tangsheng ^{[2
]}

Lu, Timothy T. ^{[3
]}

Ghilardi, Nico ^{[4
]}

机构：

[1] Genentech Inc, Biomarker Discovery, San Francisco, CA USA

[2] Genentech Inc, Dept Immunol, San Francisco, CA USA

[3] Genentech Inc, Early Clin Dev, San Francisco, CA USA

[4] DiCE Mol, San Francisco, CA 94080 USA

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 2020年 / 217卷 / 03期

关键词：

INNATE LYMPHOID-CELLS; VERSUS-HOST-DISEASE; EPITHELIAL-CELLS; COLORECTAL-CANCER; TIGHT JUNCTIONS; MUCUS LAYERS; COLON-CANCER; SERUM-LEVELS; STEM-CELLS; INTERLEUKIN-22;

D O I：

10.1084/jem.20192195

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The cytokine interleukin-22 (IL-22) is a critical regulator of epithelial homeostasis. It has been implicated in multiple aspects of epithelial barrier function, including regulation of epithelial cell growth and permeability, production of mucus and antimicrobial proteins (AMPs), and complement production. In this review, we focus specifically on the role of IL-22 in the intestinal epithelium. We summarize recent advances in our understanding of how IL-22 regulates homeostasis and host defense, and we discuss the IL-22 pathway as a therapeutic target in diseases of the intestine, including inflammatory bowel disease (IBD), graft-versus-host disease (GVHD), and cancer.

引用

页数：9

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